McCormick J L, McKee T C, Cardellina J H, Leid M, Boyd M R
Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
J Nat Prod. 1996 Nov;59(11):1047-50. doi: 10.1021/np960541v.
Bioassay-guided fractionation of an extract of a marine sponge, Stelletta sp., has led to the isolation and characterization of four new cytotoxic isomalabaricane triterpenes, named stellettins C (1), D (2), E (3), and F (4). Three known triterpenes (5-7) were also isolated from the same extract. The most sensitive of the tested cell lines (e.g., leukemia, central nervous system, renal) generally responded with GI50 concentrations in the low-to-mid nanomolar range.
对一种海洋海绵Stelletta sp.提取物进行生物测定导向的分级分离，已导致分离并鉴定出四种新的具有细胞毒性的异马拉巴烷三萜，命名为stellettins C（1）、D（2）、E（3）和F（4）。还从同一提取物中分离出三种已知的三萜（5 - 7）。在测试的细胞系（例如白血病、中枢神经系统、肾脏细胞系）中，最敏感的细胞系通常在低至中纳摩尔范围内的GI50浓度下产生反应。
