Sera Yutaka, Adachi Kyoko, Fujii Kiyonaga, Shizuri Yoshikazu
Marine Biotechnology Institute, 75-1 Heita, Kamaishi 026-0001, Japan.
J Nat Prod. 2003 May;66(5):719-21. doi: 10.1021/np020271i.
Bioassay-guided fractionation of an extract of the sponge Haliclona sp. provided a known hexapeptide, waiakeamide (1), and a new sulfone derivative (2). The structures of hexapeptides 1 and 2 were elucidated by extensive NMR analyses and the advanced Marfey's method with LC/MS. These compounds showed repellent activity against the blue mussel, Mytilus edulis galloprovincialis.
对海绵Haliclona sp.提取物进行生物测定导向的分级分离，得到了一种已知的六肽waiakeamide（1）和一种新的砜衍生物（2）。通过广泛的核磁共振分析以及采用液相色谱/质谱联用的先进马尔菲方法阐明了六肽1和2的结构。这些化合物对蓝贻贝Mytilus edulis galloprovincialis表现出驱避活性。
