Hole K, Johnson G E, Berge O G
Pharmacol Biochem Behav. 1977 Sep;7(3):205-10. doi: 10.1016/0091-3057(77)90135-6.
Rats were injected stereotactically in mesencephalon with 5,7-dihydroxytryptamine (5,7-DHT) in the medial 5-hydroxytryptamine (5-HT) pathway (n = 8) and in the medial plus the lateral 5-HT pathways (n = 7) or injected with vehicle (n = 8), or sham-operated (n = 8). The 5,7-DHT lesions reduced the in vitro 3H-5-HT uptake in the hypothalamus and the cortex cerebri to 27-51% of control values, 3H-noradrenaline uptake was not significantly changed. 5,7-DHT lesions of the medial, and of the medial plus the lateral, 5-HT induced mouse killing behavior and increased number of boxing positions in the shock elicited fighting test. Both lesions also reduced the rate of habituation to touch, but only the lesion of the medial plus the lateral 5-HT pathway significantly reduced the rate of habituation to acoustic stimulation. Activity in the home cage was not significantly changed by the lesions. It was concluded that selective chemical lesions of the ascending 5-HT pathways result in prolonged habituation of the orienting response and increase in particular components of agonistic behavior. The increase in locomotor activity observed after electrolytic lesions of nucleus raphe medianus seems not to be due only to lesion of the 5-HT neurons ascending from this nucleus.
将大鼠立体定位注射5,7 - 二羟基色胺（5,7 - DHT）至中脑内侧5 - 羟色胺（5 - HT）通路（n = 8）、内侧加外侧5 - HT通路（n = 7），或注射溶剂（n = 8），或进行假手术（n = 8）。5,7 - DHT损伤使下丘脑和大脑皮层中体外3H - 5 - HT摄取量降至对照值的27% - 51%，3H - 去甲肾上腺素摄取量无显著变化。内侧以及内侧加外侧5 - HT的5,7 - DHT损伤诱发小鼠杀戮行为，并增加电击诱发格斗试验中的拳击姿势数量。两种损伤还降低了对触摸的习惯化速率，但只有内侧加外侧5 - HT通路的损伤显著降低了对声音刺激的习惯化速率。损伤对笼内活动无显著影响。得出结论：上行5 - HT通路的选择性化学损伤导致定向反应的习惯化延长，并增加了攻击行为的特定成分。中缝正中核电解损伤后观察到的运动活动增加似乎不仅仅是由于从此核上行的5 - HT神经元损伤所致。
