小鼠中载体蛋白敏感性的母胎转移
The materno-foetal transfer of carrier protein sensitivity in the mouse.
作者信息
Stern C M
出版信息
Immunology. 1976 Mar;30(3):443-8.
The anti-dinitrophenol (DNP) antibody response was examined in the 18-week-old offspring of female mice primed to bovine serum albumin (BSA) and in control unprimed animals. Comparisons were made of the response to DNP-BSA, DNP-chicken gamma-globulin (CGG) and DNP-purified protein derivative (PPD) after all offspring had been primed with DNP-CGG at 12 weeks of age. An enhanced anti-DNP antibody response was found to DNP-BSA in mice whose mothers had received BSA. It is suggested that this phenomenon demonstrates the transfer of carrier protein sensitivity from mother to foetus.
在经牛血清白蛋白（BSA）致敏的雌性小鼠18周龄后代以及未致敏的对照动物中检测了抗二硝基苯酚（DNP）抗体反应。在所有后代于12周龄用DNP-鸡γ球蛋白（CGG）致敏后，比较了它们对DNP-BSA、DNP-鸡γ球蛋白（CGG）和DNP-纯化蛋白衍生物（PPD）的反应。发现其母亲曾接受BSA的小鼠对DNP-BSA的抗DNP抗体反应增强。提示该现象表明载体蛋白敏感性从母亲转移至胎儿。
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