Delini-Stula A
Eur J Pharmacol. 1977 Dec 1;46(3):265-74. doi: 10.1016/0014-2999(77)90342-9.
The effects of baclofen, a gamma-aminobutyric acid derivative, on conditioned avoidance behaviour and on the turning produced by unilateral 6-OHDA lesions of the s. nigra were investigated in rats. The small impairment of conditioned avoidance behaviour induced by baclofen (1-4 mg/kg i.p.) was potentiated by combination with benztropine, an anticholinergic agent. Moreover, baclofen reversed the suppression of avoidance responses and the inhibition of turning induced by physostigmine, suggesting an interaction of baclofen with cholinergic transmission processes at the nigrostriatal level. After alpha-methyltyrosine, baclofen like haloperidol, produced a marked increase in avoidance response failures suggesting an additional inhibitory effect of the compound on dopaminergic transmission. The pattern of results indicates that baclofen affects the feedback-loop regulation processes in the nigrostriatal area of the brain.
在大鼠中研究了γ-氨基丁酸衍生物巴氯芬对条件性回避行为以及对单侧6-羟基多巴胺损伤黑质所产生的旋转行为的影响。巴氯芬（1-4毫克/千克腹腔注射）引起的条件性回避行为的轻微损伤，与抗胆碱能药物苯海索联合使用时会增强。此外，巴氯芬逆转了毒扁豆碱引起的回避反应抑制和旋转抑制，表明巴氯芬在黑质纹状体水平与胆碱能传递过程相互作用。α-甲基酪氨酸处理后，巴氯芬与氟哌啶醇一样，使回避反应失败显著增加，表明该化合物对多巴胺能传递有额外的抑制作用。结果模式表明，巴氯芬影响大脑黑质纹状体区域的反馈回路调节过程。
