Ahlenius S, Carlsson A, Engel J
J Neural Transm. 1975;36(3-4):327-33. doi: 10.1007/BF01253132.
Male rats were trained to performa conditioned avoidance response combined with a successive discrimination in a shuttle-box. The administration of -amphetamine, 4 mg/kg i.p., caused a disruption of the discriminative but not thee avoidance behavior. Baclophen (beta-[-4-clorophenyl]-psi-aminobutyric acid), a GBA-derivative, given in a dose (4 mg/kg i.p.) that had no effect per se on the behavior in this test situation antagonized the -amphetamine-induced hypermotility. The present findins that baclophen antagonized a biochemically induced abnormal behaviour point to an "antipsychotic" action of baclophen in a successive discrimination avoidance test.
雄性大鼠在穿梭箱中接受训练，以执行条件性回避反应并进行连续辨别。腹腔注射4毫克/千克的安非他明会破坏辨别行为，但不会影响回避行为。巴氯芬（β-[-4-氯苯基]-ψ-氨基丁酸），一种γ-氨基丁酸衍生物，以4毫克/千克腹腔注射的剂量给药，该剂量本身对本测试情境中的行为没有影响，但能拮抗安非他明诱导的运动亢进。目前发现巴氯芬拮抗生化诱导的异常行为，这表明在连续辨别回避测试中巴氯芬具有“抗精神病”作用。
