Anke T, Oberwinkler F, Steglich W, Schramm G
J Antibiot (Tokyo). 1977 Oct;30(10):806-10. doi: 10.7164/antibiotics.30.806.
The strobilurins are two antifungal antibiotics which were isolated from the mycelium of Strobilurus tenacellus strain No. 21602. The strobilurins A and B are highly active against yeasts and filamentous fungi. In vitro antitumor activity was tested using cells of the ascitic form of EHRLICH carcinoma. The strobilurins strongly inhibited the incorporation of radioactive leucine, uridine, and thymidine into the acid-insoluble fraction of cells (protein, RNA, and DNA). The molecular formulas as determined by high resolution mass spectrometry are C16H18O3 for strobilurin A and C17H19C1O4 for strobilurin B.
嗜球果伞素是从嗜球果伞菌株21602的菌丝体中分离出的两种抗真菌抗生素。嗜球果伞素A和B对酵母和丝状真菌具有高活性。使用艾氏腹水癌腹水形式的细胞测试了其体外抗肿瘤活性。嗜球果伞素强烈抑制放射性亮氨酸、尿苷和胸苷掺入细胞的酸不溶性部分（蛋白质、RNA和DNA）。通过高分辨率质谱法测定的分子式，嗜球果伞素A为C16H18O3，嗜球果伞素B为C17H19C1O4。
