Jährig K, Wüchner U
Zentralbl Gynakol. 1985;107(13):821-6.
Consanguineous relatives (parents, siblings) of patients with myelodysplasia show an increased incidence of spina bifida occulta compared to a normal population. According to this and considering the obvious familiarity of neural tube defects, in all cases of a spina bifida occulta known in relatives a high-risk-screening (AFP, B-scan ultrasound) should be performed during early pregnancy. Patients with a spina bifida occulta should be informed about their anomaly and in case of pregnancy instruct the obstetrician to provide a careful screening examination.
与正常人群相比，骨髓发育异常患者的近亲（父母、兄弟姐妹）隐性脊柱裂发病率更高。据此，并考虑到神经管缺陷明显具有家族性，对于亲属中已知患有隐性脊柱裂的所有病例，应在孕早期进行高危筛查（甲胎蛋白、B超）。应告知隐性脊柱裂患者本人其病情异常，并在其怀孕时指导产科医生进行仔细的筛查检查。
