Burden H W, Lawrence I E
Neuroendocrinology. 1977;23(6):368-78. doi: 10.1159/000122685.
Hemiovariectomized rats were randomly assigned to 1 of 5 groups: controls, 6-hydroxydopamine (6-HD)-treated, abdominal vagotomy, 6-HD-treated plus abdominal vagotomy and pelvic parasympathectomy. 15 days later all animals were sacrificed and the amount of compensatory ovarian hypertrophy (COH) was calculated. Vagotomy and vagotomy plus 6-HD treatment interrupted estrous cycles and significantly decreased COH. Vagotomized rats with both ovaries intact had disrupted estrous cycles but ovarian weights were not affected. In a subsequent study, rats in estrus were sham-operated, unilaterally ovariectomized (ULO), vagotomized, or vagotomized + ULO, and serum levels of LH and FSH were determined at 5 and 24 h. ULO caused a significant (p less than 0.05) increase in LH and FSH at 5 h. Vagotomy significantly (p less than 0.05) depressed LH and FSH levels in hemiovariectomized animals at 5 h. By 24 h LH was significantly higher in ULO than in either sham-operated (p less than 0.05) or vagotomy (p less than 0.01) groups. Also, vagotomy significantly (p less than 0.01) depressed FSH levels at 24 h. These results suggest a functional role for the vagus nerve in normal cyclic activity, COH, and gonadotrophin (Gn) secretion.
将大鼠进行半侧卵巢切除后，随机分为5组中的1组：对照组、6-羟基多巴胺（6-HD）处理组、腹部迷走神经切断组、6-HD处理加腹部迷走神经切断组和盆腔副交感神经切除术组。15天后，处死所有动物并计算代偿性卵巢肥大（COH）的量。迷走神经切断术以及迷走神经切断术加6-HD处理中断了发情周期，并显著降低了COH。双侧卵巢完整的迷走神经切断大鼠发情周期紊乱，但卵巢重量未受影响。在随后的一项研究中，对处于发情期的大鼠进行假手术、单侧卵巢切除（ULO）、迷走神经切断术或迷走神经切断术 + ULO，并在5小时和24小时测定血清LH和FSH水平。ULO在5小时时导致LH和FSH显著（p < 0.05）升高。迷走神经切断术在5小时时显著（p < 0.05）降低了半侧卵巢切除动物的LH和FSH水平。到24小时时，ULO组的LH显著高于假手术组（p < 0.05）或迷走神经切断术组（p < 0.01）。此外，迷走神经切断术在24小时时显著（p < 0.01）降低了FSH水平。这些结果表明迷走神经在正常周期性活动、COH和促性腺激素（Gn）分泌中具有功能性作用。
