迷走神经切断术对雄性大鼠去势后促性腺激素分泌的影响。

Effect of vagotomy on postcastration gonadotropin secretion in male rats.

作者信息

Allen L G, Hodson C A, Burden H W, Lawrence I E

出版信息

Proc Soc Exp Biol Med. 1983 Sep;173(4):613-9. doi: 10.3181/00379727-173-41695.

Abstract

The postcastration increase in gonadotropins was studied in intact and vagotomized male rats. Rats underwent vagotomy or sham surgery immediately prior to castration. In the first experiment, rats were bled before castration and at 1, 2, 4, and 7 days after castration. Serum LH and FSH were significantly lower in vagotomized rats 1 day after castration. On days 2, 4, and 7 postcastration, serum gonadotropin levels were generally not different among experimental groups. In a second experiment, rats were decapitated at 12 or 24 hr after surgery and castration. Trunk blood was collected for assay of LH. Vagotomy had no effect on LH levels at 12 hr postcastration, but, at 24 hr postcastration, vagotomized rats had significantly lower serum LH than did sham-operated rats. These experiments indicate that vagotomy has a transient suppressive effect on gonadotropin release following castration. Such observations support the hypothesis that the vagus nerve may play a modulatory role in gonadotropin secretion.

摘要

在完整和切断迷走神经的雄性大鼠中研究了去势后促性腺激素的增加情况。大鼠在去势前立即进行迷走神经切断术或假手术。在第一个实验中，大鼠在去势前以及去势后1天、2天、4天和7天进行采血。去势后1天，切断迷走神经的大鼠血清促黄体生成素（LH）和促卵泡生成素（FSH）显著降低。在去势后的第2天、第4天和第7天，各实验组之间血清促性腺激素水平总体上没有差异。在第二个实验中，大鼠在手术和去势后12小时或24小时断头。收集躯干血用于检测LH。迷走神经切断术对去势后12小时的LH水平没有影响，但在去势后24小时，切断迷走神经的大鼠血清LH显著低于假手术大鼠。这些实验表明，迷走神经切断术对去势后促性腺激素的释放有短暂的抑制作用。这些观察结果支持了迷走神经可能在促性腺激素分泌中起调节作用的假说。