酸性磷脂对β-溶素和阳离子杀菌因子的中和作用
Neutralization of beta-lysin and cationic bactericidal agents by acidic phospholipid.
作者信息
Joos R W, Hall W H
出版信息
J Bacteriol. 1968 Jan;95(1):9-13. doi: 10.1128/jb.95.1.9-13.1968.
Abstract
Acidic phospholipids neutralized the antistaphylococcal activity of rabbit, human, and rat serum and purified rabbit beta-lysin as well. Several tissue bactericidal factors and cationic antibiotics were also neutralized. The neutralizing ability of all anionic lipids tested, together with the lack of this ability for the electrostatically neutral phosphatidylcholine, suggested that neutralization resulted from formation of electrostatic complexes between negative charges on the lipids and positive charges on the bactericidal substances. The neutralization of these host defense systems by phospholipids can explain the ability of phospholipids to increase bacterial virulence.
摘要
酸性磷脂中和了兔、人及大鼠血清以及纯化的兔β-溶素的抗葡萄球菌活性。几种组织杀菌因子和阳离子抗生素也被中和。所测试的所有阴离子脂质的中和能力，以及静电中性的磷脂酰胆碱缺乏这种能力，表明中和是由于脂质上的负电荷与杀菌物质上的正电荷形成静电复合物所致。磷脂对这些宿主防御系统的中和作用可以解释磷脂增加细菌毒力的能力。
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