3-乙酰基-5-（4-氟亚苄基）-4-羟基-2-氧代-2,5-二氢噻吩（ICI 47,776）的免疫抑制活性
Immunosuppressive activity of 3-acetyl-5-(4-fluorobenzylidene)-4-hydroxy-2-oxo-2:5-dihydrothiophen (I.C.I. 47,776).
作者信息
Davies G E
出版信息
Immunology. 1968 Mar;14(3):393-9.
Abstract
A novel type of immunosuppressive agent, 3-acetyl-5-(4-fluorobenzylidene)4-hydroxy-2-oxo-2:5-dihydrothiophen (I.C.I. 47,776) inhibits the production of antibodies in rats when given orally. The treatment is still effective when commenced several days after immunization. No effect has been demontrated in mice or in guinea-pigs.
摘要
一种新型免疫抑制剂，3-乙酰基-5-（4-氟亚苄基）-4-羟基-2-氧代-2:5-二氢噻吩（ICI 47,776）口服给药时可抑制大鼠抗体的产生。免疫接种几天后开始治疗仍有效。在小鼠或豚鼠中未显示出效果。
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Biochemical studies with a new cytotoxic immunosuppressive agent, 3-acetyl-5-(4-fluorobenzylidene)-2,5-dihydro-4-hydroxy-2-oxothiophen (I.C.I. 47776).用新型细胞毒性免疫抑制剂 3-乙酰基-5-(4-氟亚苄基)-2,5-二氢-4-羟基-2-氧代噻吩（ICI 47776）进行生化研究。
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