Smith J W, Wherry P J
J Hyg (Lond). 1978 Feb;80(1):155-67. doi: 10.1017/s0022172400053481.
Poliomyelitis continued to be a rare disease in England and Wales in the period 1969-75. Only 31 paralytic and 44 cases of possible non-paralytic poliomyelitis were recorded during the 7 years. Of the 31 paralytic cases approximately one third were vaccine-associated; 3 were patients who had recently received oral poliovaccine and 7 had been in contact with a vaccinated person. Five of these 7 patients were parents of recently vaccinated children. The rate of vaccine-associated poliomyelitis was estimated in recipients to be 0.2 and in contacts 0.4 per million doses of vaccine given. Marker test results were reported on 555 strains of poliomyelitis virus isolated during 1969-75, using the reproductive capacity temperature test. Forty-eight (8.6%) resembled wild virus in this property, 15 strains being type 1, 8 type 2 and 25 type 3. Most of these isolations of apparently wild virus were from excreters with no symptoms of poliomyelitis, although 3 of the 15 type 1 strains were from patients with paralytic poliomyelitis and 3 from possible cases of non-paralytic poliomyelitis. None of the 8 apparently wild type 2 viruses was from a case of paralytic illness and only 1 of the 39 type 3 strains. Eleven of the 31 paralytic cases were in patients in whom the infection was likely to have been acquired abroad.
1969年至1975年期间，脊髓灰质炎在英格兰和威尔士仍然是一种罕见疾病。在这7年中，仅记录到31例麻痹型和44例可能的非麻痹型脊髓灰质炎病例。在31例麻痹型病例中，约三分之一与疫苗相关；3例为近期接受口服脊髓灰质炎疫苗的患者，7例与接种疫苗的人有过接触。这7例患者中有5例是近期接种疫苗儿童的父母。据估计，疫苗接种者中疫苗相关脊髓灰质炎的发生率为每百万剂疫苗0.2例，接触者为每百万剂疫苗0.4例。使用繁殖能力温度试验报告了1969年至1975年期间分离出的555株脊髓灰质炎病毒的标记试验结果。其中48株（8.6%）在这一特性上与野生病毒相似，15株为1型，8株为2型，25株为3型。这些明显为野生病毒的分离株大多来自无脊髓灰质炎症状的排泄者，不过15株1型病毒中有3株来自麻痹型脊髓灰质炎患者，3株来自可能的非麻痹型脊髓灰质炎病例。8株明显为野生型2病毒中无一株来自麻痹性疾病病例，39株3型病毒中只有1株来自麻痹性疾病病例。31例麻痹型病例中有11例患者的感染可能是在国外获得的。
