Henderson K M, Swanston I A
J Reprod Fertil. 1978 Jan;52(1):131-4. doi: 10.1530/jrf.0.0520131.
Luteinized bovine granulosa cells in tissue culture contained an active 19-hydroxylase aromatase enzyme system which converted exogenous androstenedione and testosterone to oestradiol-17beta; no oestrone was detected. In the absence of exogenous androgens, the cells failed to synthesize oestrogens due to a limited capacity to synthesize androgen precursor. Theca-lutein cells, present in those CL which synthesize oestrogens, may provide androgen precursor for aromatization by the granulosa-lutein cells.
组织培养中的黄体化牛颗粒细胞含有一种活性19-羟化酶芳香化酶系统，该系统可将外源性雄烯二酮和睾酮转化为雌二醇-17β；未检测到雌酮。在没有外源性雄激素的情况下，由于合成雄激素前体的能力有限，这些细胞无法合成雌激素。存在于那些合成雌激素的黄体中的卵泡膜黄体细胞，可能为颗粒黄体细胞的芳香化作用提供雄激素前体。
