免疫耐受诱导机制。IV. 超低剂量鞭毛蛋白的作用。
Mechanism of induction of immunological tolerance. IV. The effects of ultra-low doses of flagellin.
作者信息
Shellam G R, Nossal G J
出版信息
Immunology. 1968 Feb;14(2):273-84.
Minute amounts of flagellin were shown to be capable of inducing tolerance in newborn Wistar rats. With the range of doses, 10–10 μg, the following results were obtained: (1) Tolerance could be induced in two zones of dosage by daily injections of flagellin during the first 2 weeks of life. The low zone corresponded to a dose of 10 μg/g body weight and the high zone to 10 μg/g body weight. Doses between these evoked an immune response. (2) Daily injections of flagellin for 6 weeks resulted in a shift in the dosage required for low zone tolerance from 10 μg/g body weight to 10 μg/g body weight. (3) The events of low zone tolerance occurred at an antigen concentration, which, in an organ such as the spleen of a newborn rat, never exceeded about 10 M. The high zone of tolerance corresponded to an antigen concentration of about 10 M.
已表明微量鞭毛蛋白能够诱导新生Wistar大鼠产生耐受性。在10⁻¹⁰ μg的剂量范围内，获得了以下结果：(1) 在出生后的前2周，通过每日注射鞭毛蛋白，可在两个剂量区诱导耐受性。低剂量区对应于10⁻¹⁰ μg/g体重的剂量，高剂量区对应于10⁻⁷ μg/g体重的剂量。这两个剂量之间的剂量会引发免疫反应。(2) 每日注射鞭毛蛋白6周导致低剂量区耐受性所需的剂量从10⁻¹⁰ μg/g体重转变为10⁻⁷ μg/g体重。(3) 低剂量区耐受性事件发生的抗原浓度，在新生大鼠脾脏等器官中，从未超过约10⁻⁹ M。高剂量区耐受性对应于约10⁻⁷ M的抗原浓度。
Zotero 插件