Schumacher K, Uhlenbruck G, Chatterjee B P, Steinhausen G, Vaith P, van Mil A
Z Immunitatsforsch Immunobiol. 1978;154(1):62-72.
In the haemolymph of the Tridacnid bivalve clams anti-galactans occur which do not have only glycosubstance precipitating and cell agglutinating properties, but also show mitogenic activity with respect to the blast transformation of human peripheral lymphocytes. This new property can be inhibited in a specific way by galactans and is destroyed by the degradation of the mitogenic lectin into subunits by polymer bound pronase. Quite a number of invertebrate haemolymph samples and snail albumin gland extracts, containing agglutinin activity, proved to have no mitogenic potency. The only exception was found in an extract of the snail albumin gland of Ampullaria canaliculata which contained a strong mitogen of the lectin type.
在巨蛤双壳贝类的血淋巴中存在抗半乳糖聚糖，它们不仅具有使糖物质沉淀和细胞凝集的特性，而且对人外周淋巴细胞的母细胞转化表现出促有丝分裂活性。这种新特性可被半乳糖聚糖以特定方式抑制，并且通过聚合物结合的链霉蛋白酶将促有丝分裂凝集素降解为亚基而被破坏。相当多具有凝集素活性的无脊椎动物血淋巴样本和蜗牛白蛋白腺提取物被证明没有促有丝分裂能力。唯一的例外是在管角螺蜗牛白蛋白腺提取物中发现了一种强凝集素型促有丝分裂原。
