Cucuianu M, Fekete T, Marcusiu C, Mösler R, Duţu A
Med Interne. 1984 Jul-Sep;22(3):171-7.
The variations of dilute blood clot lysis time (DBCLT) in 103 diabetic patients were investigated in terms of insulin dependency, body weight, serum lipids and presence of diabetic vascular diseases. The results showed that DBCLT was significantly longer in the 34 overweight diabetic patients (437 +/- 68 min) than in the 69 diabetics at or below the ideal body weight (240 +/- 28 min) or in the 76 normalipidemic normal weight control subjects (253 +/- 12 min). DBCLT was also longer in the hypertrigliceridemic diabetic patients than in the normolipidemic ones. The mean lysis time was similar in diabetic patients with and without retinopathy. However, a higher level of fibrinolytic inhibitors was found in patients with diabetic small vessel disease. In vitro inhibition of plasma factor XIII by p-chlormercuribenzoate (PCMB) caused an acceleration of DBCLT and the differences between lysis time in the overweight diabetics and in the controls were attenuated. These results suggested that deficient thrombolysis is rather due to overweight and to disturbances of lipid metabolism than to diabets and/or its vascular complications and that enhanced fibrin crosslinking is at least partially responsible for delayed clot lysis.
对103例糖尿病患者的稀释血液凝块溶解时间（DBCLT）在胰岛素依赖、体重、血脂及糖尿病血管疾病的存在等方面的变化进行了研究。结果显示，34例超重糖尿病患者的DBCLT（437±68分钟）显著长于69例体重处于或低于理想体重的糖尿病患者（240±28分钟）或76例血脂正常的正常体重对照者（253±12分钟）。高甘油三酯血症糖尿病患者的DBCLT也长于血脂正常者。有视网膜病变和无视网膜病变的糖尿病患者的平均溶解时间相似。然而，糖尿病小血管疾病患者中发现纤溶抑制剂水平较高。对氯汞苯甲酸（PCMB）对血浆因子XIII的体外抑制导致DBCLT加快，超重糖尿病患者与对照者的溶解时间差异减小。这些结果表明，溶栓不足相当程度上是由于超重和脂质代谢紊乱，而非糖尿病和/或其血管并发症，并且纤维蛋白交联增强至少部分导致凝块溶解延迟。
