药物对物质跨毛细血管和小静脉转运的影响。
The effect of drugs on mass transport across capillaries and venules.
作者信息
Smaje L H
出版信息
Bibl Anat. 1977(16 Pt 2):318-21.
PMID:564182
Abstract
- The single vessel occlusion technique has been applied to venules to investigate the effect of drugs on mass transfer. 2. The filtration coefficient in venules is greater than that in capillaries and in both types of vessel the filtration coefficient is negatively correlated with hydrostatic pressure. 3. Vasoactive drugs have no effect on capillary filtration coefficient. 4. Acetylcholine and isoprenaline do not increase vanular filtration coefficient but histamine, bradykinin, 5-Ht and SPF do and may do so independently of protein leakage.
摘要
- 单血管闭塞技术已应用于微静脉，以研究药物对物质转运的影响。2. 微静脉的滤过系数大于毛细血管，且在这两种血管中，滤过系数均与流体静压呈负相关。3. 血管活性药物对毛细血管滤过系数无影响。4. 乙酰胆碱和异丙肾上腺素不会增加微静脉滤过系数，但组胺、缓激肽、5-羟色胺和速激肽会增加，且可能独立于蛋白质渗漏而增加。
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