巴氯芬对大鼠α-氟哌噻吨诱导的僵住症的影响。
The effect of baclofen on alpha-flupenthixol-induced catalepsy in the rat.
作者信息
Davies J A, Williams J
出版信息
Br J Pharmacol. 1978 Feb;62(2):303-5. doi: 10.1111/j.1476-5381.1978.tb08460.x.
Abstract
1 alpha-Flupenthixol (alpha-FPT; 0.2 mg/kg i.p.) when administered to rats produced catalepsy. 2 Baclofen (10 mg/kg i.p.) given 30 min after alpha-FPT had a biphasic effect on the catalepsy. Initially there was a potentiation of the effect, followed by a significant attenuation of the degree of catalepsy. 3 Possible mechanisms of action are discussed.
摘要
- 给大鼠腹腔注射1α-氟哌噻吨（α-FPT；0.2毫克/千克）会导致僵住症。2. 在α-FPT注射30分钟后给予巴氯芬（10毫克/千克腹腔注射）对僵住症有双相作用。最初作用增强，随后僵住症程度显著减轻。3. 讨论了可能的作用机制。
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