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巴氯芬对大鼠α-氟哌噻吨诱导的僵住症的影响。

The effect of baclofen on alpha-flupenthixol-induced catalepsy in the rat.

作者信息

Davies J A, Williams J

出版信息

Br J Pharmacol. 1978 Feb;62(2):303-5. doi: 10.1111/j.1476-5381.1978.tb08460.x.

DOI:10.1111/j.1476-5381.1978.tb08460.x
PMID:564220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1667811/
Abstract

1 alpha-Flupenthixol (alpha-FPT; 0.2 mg/kg i.p.) when administered to rats produced catalepsy. 2 Baclofen (10 mg/kg i.p.) given 30 min after alpha-FPT had a biphasic effect on the catalepsy. Initially there was a potentiation of the effect, followed by a significant attenuation of the degree of catalepsy. 3 Possible mechanisms of action are discussed.

摘要
  1. 给大鼠腹腔注射1α-氟哌噻吨（α-FPT；0.2毫克/千克）会导致僵住症。2. 在α-FPT注射30分钟后给予巴氯芬（10毫克/千克腹腔注射）对僵住症有双相作用。最初作用增强，随后僵住症程度显著减轻。3. 讨论了可能的作用机制。

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引用本文的文献

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Psychopharmacology (Berl). 1979 Jun 28;64(1):81-3. doi: 10.1007/BF00427349.

本文引用的文献

1
EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.氯丙嗪或氟哌啶醇对小鼠脑内3-甲氧基酪胺和去甲变肾上腺素形成的影响。
Acta Pharmacol Toxicol (Copenh). 1963;20:140-4. doi: 10.1111/j.1600-0773.1963.tb01730.x.
2
The significance of dopamine-receptor blockade for the mechanism of action of neuroleptic drugs.多巴胺受体阻断对抗精神病药物作用机制的意义。
Arch Int Pharmacodyn Ther. 1966 Apr;160(2):492-4.
3
Role of -aminobutyric acid (GABA) in the extrapyramidal motor system. 2. Some evidence for the existence of a type of GABA-rich strio-nigral neurons.γ-氨基丁酸（GABA）在外锥体系运动系统中的作用。2. 关于一类富含GABA的纹状体-黑质神经元存在的一些证据。
Exp Brain Res. 1971;14(1):95-104. doi: 10.1007/BF00234913.
4
The comparative pharmacology of flupenthixol and some reference neuroleptics.氟哌噻吨与一些对照抗精神病药物的比较药理学
Acta Pharmacol Toxicol (Copenh). 1973;33(5):353-62. doi: 10.1111/j.1600-0773.1973.tb01537.x.
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The importance of the ascending dopaminergic systems to the extrapyramidal and mesolimbic brain areas for the cataleptic action of the neuroleptic and cholinergic agents.上行多巴胺能系统对锥体外系和中脑边缘脑区在抗精神病药和胆碱能药物致僵作用方面的重要性。
Neuropharmacology. 1974 May;13(5):353-64. doi: 10.1016/0028-3908(74)90118-x.
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Med Biol. 1975 Jun;53(3):177-83.
7
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Adv Biochem Psychopharmacol. 1975(14):131-51.
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