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诱导新生豚鼠某些脑线粒体反应发生变化的未结合胆红素的血清水平。

The serum levels of unbound bilirubin that induce changes in some brain mitochondrial reactions in newborn guinea-pigs.

作者信息

Almeida M A, Rezende L

出版信息

Experientia. 1981;37(8):807-9. doi: 10.1007/BF01985651.

DOI:10.1007/BF01985651
PMID:6456926
Abstract

Bilirubin in different concentrations was injected in newborn guinea-pigs and the following parameters were determined: serum total and unbound bilirubin, whole brain bilirubin content and oxygen consumption, NADH-cytochrome c reductase and ATPase activities in brain mitochondria. The results showed a significant correlation between decreased rates of brain metabolism and the elevation of serum total and unbound bilirubin.

摘要

将不同浓度的胆红素注入新生豚鼠体内，并测定以下参数：血清总胆红素和未结合胆红素、全脑胆红素含量、氧消耗量、脑线粒体中NADH-细胞色素c还原酶和ATP酶活性。结果表明，脑代谢率降低与血清总胆红素和未结合胆红素升高之间存在显著相关性。

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引用本文的文献

1
The Effects of Bilirubin and Lumirubin on Metabolic and Oxidative Stress Markers.胆红素和光胆红素对代谢及氧化应激标志物的影响
Front Pharmacol. 2021 Mar 4;12:567001. doi: 10.3389/fphar.2021.567001. eCollection 2021.

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Experimental bilirubin encephalopathy. The mode of entry of bilirubin-14C into the central nervous system.实验性胆红素脑病。胆红素-14C进入中枢神经系统的途径。
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Improved micro-method for determination of serum bilirubin.改进的血清胆红素测定微量方法。
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Mitochondrial abnormalities in bilirubin encephalopathy.胆红素脑病中的线粒体异常。
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Effects of bilirubin on mitochondrial reactions.胆红素对线粒体反应的影响。
J Biol Chem. 1969 Dec 10;244(23):6403-14.
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Determination of unbound bilirubin in the serum of newborns.新生儿血清中游离胆红素的测定。
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10
Clinical application of neonatal bilirubin-binding determinations: current status.新生儿胆红素结合测定的临床应用：现状
J Pediatr. 1978 Nov;93(5):827-33. doi: 10.1016/s0022-3476(78)81095-6.