双小核草履虫DNA中的嘧啶二聚体。
Pyrimidine dimers in the DNA of Paramecium aurelia.
作者信息
Sutherland B M, Carrier W L, Setlow R B
出版信息
Biophys J. 1968 Apr;8(4):490-9. doi: 10.1016/S0006-3495(68)86502-6.
Abstract
The production and fate of thymine-containing pyrimidine dimers in Paramecium aurelia DNA was investigated in three experimental series: production of dimers by UV irradiation, fate of dimers in the dark, and "loss of photoreactivability of dimers." It is shown that cyclobutyl dimers are made by UV irradiation of Paramecium DNA in vivo, that because of cytoplasmic absorption the number of dimers made in DNA irradiated in vivo is much lower than in DNA irradiated in vitro, that dimers are lost from animals incubated in the dark after irradiation, and that all the dimers that remain in the animals can be destroyed by photoreactivating illumination. Since mutation induction is photoreactivable, these and previous photoreactivation data suggest that pyrimidine dimers are important in mutation induction in P. aurelia.
摘要
在三个实验系列中研究了草履虫（Paramecium aurelia）DNA中含胸腺嘧啶嘧啶二聚体的产生和命运：紫外线照射产生二聚体、黑暗中二聚体的命运以及“二聚体光复活能力的丧失”。结果表明，环丁烷二聚体是通过紫外线在体内照射草履虫DNA产生的，由于细胞质吸收，体内照射的DNA中产生的二聚体数量远低于体外照射的DNA，二聚体在照射后在黑暗中孵育的动物体内会丢失，并且动物体内残留的所有二聚体都可以通过光复活照射被破坏。由于突变诱导是可光复活的，这些以及之前的光复活数据表明嘧啶二聚体在草履虫的突变诱导中很重要。
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