吖啶染料抑制脱氧核糖核酸中嘧啶二聚体形成的机制。
Mechanisms of inhibition of pyrimidine dimer formation in deoxyribonucleic acid by acridine dyes.
作者信息
Sutherland B M, Sutherland J C
出版信息
Biophys J. 1969 Mar;9(3):292-302. doi: 10.1016/S0006-3495(69)86387-3.
Abstract
The ultraviolet (UV)-induced formation of cyclobutyl pyrimidine dimers in Escherichia coli deoxyribonucleic acid (DNA) in vitro has been investigated in terms of the mechanism of inhibition by acridine dyes, the effect on dimer yield of specific singlet and triplet quenchers, and the mechanism of dimer formation. Our results indicate that (a) energy transfer is important in dimer reduction by acridines, (b) this transfer occurs from the singlet (S(1)) of DNA, and (c) at room temperature triplet quenchers do not reduce dimer yield in DNA.
摘要
已从吖啶染料的抑制机制、特定单重态和三重态猝灭剂对二聚体产量的影响以及二聚体形成机制等方面，对紫外线（UV）诱导大肠杆菌脱氧核糖核酸（DNA）中形成环丁基嘧啶二聚体进行了体外研究。我们的结果表明：（a）能量转移在吖啶类物质减少二聚体形成过程中很重要；（b）这种转移发生于DNA的单重态（S(1)）；（c）在室温下，三重态猝灭剂不会降低DNA中的二聚体产量。
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