Meltzer H
Science. 1968 Mar 22;159(3821):1368-70. doi: 10.1126/science.159.3821.1368.
Activity of creatine kinase and aldolase in serum increased in 14 of 16 patients with recent onset of a psychotic reaction, and in five of six patients treated with psychotomimetic drugs. There was either no increase of these enzymes or a slight increase in severely agitated (or depressed) non-psychotic hospitalized patients and chronic psychotic patients. The increase of the enzymes preceded the onset of the acute psychotic symptoms in at least three cases, was highest during the first 2 weeks of a psychotic episode, and sometimes recurred throughout the illness, particularly at times of stress. The creatine kinase in the serum is primarily of the muscle type.
16例近期出现精神反应的患者中，14例血清肌酸激酶和醛缩酶活性升高；6例接受拟精神病药物治疗的患者中，5例出现上述情况。在严重躁动（或抑郁）的非精神病住院患者和慢性精神病患者中，这些酶要么没有升高，要么仅有轻微升高。至少在3例患者中，酶的升高先于急性精神病症状的出现，在精神病发作的前2周最高，有时在整个病程中反复出现，尤其是在应激时。血清中的肌酸激酶主要是肌肉型的。
