Segal Michael, Avital Avi, Drobot Marina, Lukanin Aida, Derevenski Andrei, Sandbank Sergio, Weizman Abraham
Flügelman's (Mazra) Mental Health Medical Center, Acre, Israel.
Eur Neuropsychopharmacol. 2007 Feb;17(3):194-8. doi: 10.1016/j.euroneuro.2006.08.010. Epub 2006 Oct 16.
Creatine kinase (CK) level was previously found to be increased in the majority of hospitalized acute psychotic patients. We aimed to asses the possible differences in CK level in various forms of depression: major with and without psychotic symptoms, of bipolar depression and schizoaffective depression. Unmedicated hospitalized patients participated: nonpsychotic major depression (n=39), psychotic major depression (n=23), bipolar depression (n=23) and schizoaffective depression (n=24). The severity of depression was assessed by the Hamilton Depression Rating Scale (Ham-D) and blood samples were collected in the morning of admission day, prior to any treatment. Ham-D yielded a significantly higher score for psychotic major depression group, compared with all other groups which showed similar score. CK serum level was significantly higher in nonpsychotic major depression than in all other forms of depression. The results indicate a biological difference between the nonpsychotic major depression and the "psychotic" cluster of depressive syndromes.
先前发现，大多数住院急性精神病患者的肌酸激酶（CK）水平会升高。我们旨在评估各种形式抑郁症患者的CK水平可能存在的差异：伴有和不伴有精神病症状的重度抑郁症、双相抑郁症以及分裂情感性抑郁症。未接受药物治疗的住院患者参与了研究：非精神病性重度抑郁症患者（n = 39）、精神病性重度抑郁症患者（n = 23）、双相抑郁症患者（n = 23）以及分裂情感性抑郁症患者（n = 24）。通过汉密尔顿抑郁量表（Ham-D）评估抑郁严重程度，并在入院当天早晨、任何治疗之前采集血样。与所有其他得分相似的组相比，精神病性重度抑郁症组的Ham-D得分显著更高。非精神病性重度抑郁症患者的CK血清水平显著高于所有其他形式的抑郁症患者。结果表明，非精神病性重度抑郁症与抑郁综合征的“精神病性”类别之间存在生物学差异。
