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1-反式-Δ⁹-四氢大麻酚对吗啡依赖小鼠纳洛酮诱导戒断反应的抑制作用

Inhibition of naloxone-induced withdrawal in morphine dependent mice by 1-trans-delta9-tetrahydrocannabinol.

作者信息

Bhargava H N

出版信息

Eur J Pharmacol. 1976 Mar;36(1):259-62. doi: 10.1016/0014-2999(76)90283-1.

DOI:10.1016/0014-2999(76)90283-1
PMID:944134
Abstract

The effects of various doses of 1-trans-delta9-tetrahydrocannabinol (delta9-THC) on naloxone-induced withdrawal were studied in mice rendered dependent on morphine by the pellet implantation procedure. When administered i.p., 30 min prior to naloxone, delta9-THC, inhibited the naloxone-induced withdrawal jumping response. Two other signs of morphine withdrawal (defecation and rearing behavior) were also suppressed by deltapTHC. It is suggested that delta9-THC or some of its derivatives may have potential use in narcotic detoxification.

摘要

通过植入药丸的方法使小鼠对吗啡产生依赖性，研究了不同剂量的1-反式-δ9-四氢大麻酚（δ9-THC）对纳洛酮诱发戒断反应的影响。当在纳洛酮给药前30分钟腹腔注射时，δ9-THC抑制了纳洛酮诱发的戒断跳跃反应。吗啡戒断的另外两个体征（排便和竖毛行为）也被δ9-THC抑制。提示δ9-THC或其某些衍生物可能在麻醉品脱毒方面有潜在用途。

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