酒精的持续释放：小鼠皮下硅橡胶植入物

Sustained release of alcohol: subcutaneous silastic implants in mice.

作者信息

Erickson C K, Koch K I, Mehta C S, McGinity J W

出版信息

Science. 1978 Mar 31;199(4336):1457-9. doi: 10.1126/science.564551.

Abstract

A sustained-release device for use in ethanol dependence studies in mice is described. The Silastic device, dubbed SERT (sustained ethanol release tube), holds 0.35 milliliter of 95 percent ethanol (by volume) and is implanted under the skin of the back where it releases ethanol for up to 12 hours, with no observable tissue damage. The device may be adaptable to the release of other volatile liquids or drugs, in other animals.

摘要

描述了一种用于小鼠乙醇依赖研究的缓释装置。这种硅橡胶装置被称为SERT（持续乙醇释放管），可容纳0.35毫升95%（体积）的乙醇，并植入小鼠背部皮肤下，在那里它能持续释放乙醇长达12小时，且未观察到明显的组织损伤。该装置可能适用于在其他动物体内释放其他挥发性液体或药物。