Sagebiel R W, Reed T H
J Cell Biol. 1968 Mar;36(3):595-602. doi: 10.1083/jcb.36.3.595.
Three-dimensional models of individual granules in the same Langerhans cell were made after analyzing serial sections of human epidermis in the electron microscope. These models revealed that the granule is made up of a flattened or curved orthogonal net of particles which is bounded externally by a limiting membrane and which may be disc-shaped, cup-shaped, or combinations of both shapes. This variety of shapes accounts for the many configurations of the granule seen in individual electron micrographs. Usually, the granule has a vesicular portion at, or near one margin. This demonstration of the three-dimensional structure of the granule establishes the inaccuracy of previously used descriptive terms, the granule should be called simply the "Langerhans cell granule."
在电子显微镜下分析人表皮连续切片后，制作了同一朗格汉斯细胞中单个颗粒的三维模型。这些模型显示，颗粒由扁平或弯曲的正交颗粒网组成，其外部由限制膜界定，可能呈盘状、杯状或两种形状的组合。这种形状的多样性解释了在单个电子显微照片中看到的颗粒的多种形态。通常，颗粒在一侧边缘或其附近有一个囊泡部分。颗粒三维结构的这一展示证实了先前使用的描述性术语的不准确之处，该颗粒应简称为“朗格汉斯细胞颗粒”。
