Breit R
Arch Dermatol Res. 1982;272(3-4):401-5. doi: 10.1007/BF00509072.
A tentative model is presented which is based on existing published data. The model suggests that the epidermal Langerhans cell plays a central role in contact dermatitis by proliferation control of keratinocytes and as the most peripheral outpost of the immune system. Contact dermatitis to chemicals is the injurious expression of a defense mechanism designed phylogenetically against arthropods and insects.
本文提出了一个基于已发表数据的初步模型。该模型表明，表皮朗格汉斯细胞通过控制角质形成细胞的增殖以及作为免疫系统最外围的前哨，在接触性皮炎中发挥核心作用。对化学物质的接触性皮炎是一种在系统发育上针对节肢动物和昆虫设计的防御机制的有害表现。
