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劳斯肉瘤病毒与针对主要病毒糖蛋白的抗体形成感染性病毒 - 抗体复合物。

Formation of an infectious virus-antibody complex with Rous sarcoma virus and antibodies directed against the major virus glycoprotein.

作者信息

Schlesinger M J

出版信息

J Virol. 1976 Mar;17(3):1063-7. doi: 10.1128/JVI.17.3.1063-1067.1976.

DOI:10.1128/JVI.17.3.1063-1067.1976
PMID:56458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC515508/
Abstract

Preparations of Rous sarcoma virus (RSV) can form an infectious viral-antibody complex with antibodies raised against the major glycoprotein, gp85, isolated from avian myeloblastosis virus and Prague-RSV subgroup C. Binding of anti-gp85 antibodies to RSV can be demonstrated by the inhibition of focus-forming activity after addition of goat anti-rabbit immunoglobulin and by a shift in density of virions treated with anti-gp85 serum. Group- rather than subgroup- specific regions of viral gp85 appear to be the site of binding for infectious complex.

摘要

劳氏肉瘤病毒（RSV）制剂可与针对从禽成髓细胞瘤病毒和布拉格-RSV C亚群分离出的主要糖蛋白gp85产生的抗体形成感染性病毒-抗体复合物。抗gp85抗体与RSV的结合可通过添加山羊抗兔免疫球蛋白后焦点形成活性的抑制以及用抗gp85血清处理的病毒粒子密度的变化来证明。病毒gp85的组特异性而非亚组特异性区域似乎是感染性复合物的结合位点。

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本文引用的文献

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Expression of the Major Viral Glycoprotein of Avian Tumor Virus in Cells of chf(+) Chicken Embryos.禽肿瘤病毒主要病毒糖蛋白在chf(+)鸡胚细胞中的表达
J Virol. 1975 May;15(5):1131-40. doi: 10.1128/JVI.15.5.1131-1140.1975.
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Immune complex disease in chronic viral infections.慢性病毒感染中的免疫复合物疾病
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Identification of a second glycoprotein in Sindbis virus.辛德毕斯病毒中第二种糖蛋白的鉴定。
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The antibody response of mice to murine leukemia virus in spontaneous infection: absence of classical immunologic tolerance (AKR mice-complement-fixing antibodies-lymphocytic choriomeningitis virus-immunofluorescence-glomerular deposits of antigen-antibody complexes).小鼠在自然感染中对鼠白血病病毒的抗体反应：缺乏经典免疫耐受性（AKR小鼠-补体结合抗体-淋巴细胞性脉络丛脑膜炎病毒-免疫荧光-抗原抗体复合物的肾小球沉积物）
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Insulin-like activity of concanavalin A and wheat germ agglutinin--direct interactions with insulin receptors.伴刀豆球蛋白A和麦胚凝集素的胰岛素样活性——与胰岛素受体的直接相互作用。
Proc Natl Acad Sci U S A. 1973 Feb;70(2):485-9. doi: 10.1073/pnas.70.2.485.
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Isolation of proteins by gel filtration in 6M guanidinium chloride: application to RNA tumor viruses.在6M盐酸胍中通过凝胶过滤分离蛋白质：应用于RNA肿瘤病毒
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Electrophoretic analysis of the RNA of avian tumor viruses.禽肿瘤病毒RNA的电泳分析。
Virology. 1972 Dec;50(3):753-64. doi: 10.1016/0042-6822(72)90429-1.
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Chromatographic separation and antigenic analysis of proteins of the oncornaviruses. I. Avian leukemia-sarcoma viruses.肿瘤病毒蛋白质的色谱分离与抗原分析。I. 禽白血病-肉瘤病毒
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