劳斯肉瘤病毒与针对主要病毒糖蛋白的抗体形成感染性病毒 - 抗体复合物。
Formation of an infectious virus-antibody complex with Rous sarcoma virus and antibodies directed against the major virus glycoprotein.
作者信息
Schlesinger M J
出版信息
J Virol. 1976 Mar;17(3):1063-7. doi: 10.1128/JVI.17.3.1063-1067.1976.
Abstract
Preparations of Rous sarcoma virus (RSV) can form an infectious viral-antibody complex with antibodies raised against the major glycoprotein, gp85, isolated from avian myeloblastosis virus and Prague-RSV subgroup C. Binding of anti-gp85 antibodies to RSV can be demonstrated by the inhibition of focus-forming activity after addition of goat anti-rabbit immunoglobulin and by a shift in density of virions treated with anti-gp85 serum. Group- rather than subgroup- specific regions of viral gp85 appear to be the site of binding for infectious complex.
摘要
劳氏肉瘤病毒（RSV）制剂可与针对从禽成髓细胞瘤病毒和布拉格-RSV C亚群分离出的主要糖蛋白gp85产生的抗体形成感染性病毒-抗体复合物。抗gp85抗体与RSV的结合可通过添加山羊抗兔免疫球蛋白后焦点形成活性的抑制以及用抗gp85血清处理的病毒粒子密度的变化来证明。病毒gp85的组特异性而非亚组特异性区域似乎是感染性复合物的结合位点。
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