正常人小淋巴细胞体外合成RNA的特性及植物血凝素刺激诱导的变化。
Characteristics of the RNA synthesized in vitro by the normal human small lymphocyte and the changes induced by phytohemagglutinin stimulation.
作者信息
Torelli U L, Henry P H, Weissman S M
出版信息
J Clin Invest. 1968 May;47(5):1083-95. doi: 10.1172/JCI105798.
Abstract
These studies demonstrate that the circulating human small lymphocyte synthesizes ribonucleic acid (RNA) of high molecular weight which is not primarily a ribosomal precursor and which is, in part, complementary to human deoxyribonucleic acid (DNA). The stimulation of these lymphocytes by PHA brings a cell population in which few ribosomes are synthesized to a functional condition in which a large amount of these particles are produced. This increase in the synthesis of ribosomal RNA is one of the earliest and most relevant effects of PHA on the RNA metabolism of small lymphocytes.
摘要
这些研究表明，循环中的人类小淋巴细胞能合成高分子量的核糖核酸（RNA），这种RNA并非主要是核糖体前体，且部分与人类脱氧核糖核酸（DNA）互补。用植物血凝素（PHA）刺激这些淋巴细胞，会使核糖体合成很少的细胞群体进入能产生大量这些颗粒的功能状态。核糖体RNA合成的这种增加是PHA对小淋巴细胞RNA代谢最早且最相关的效应之一。
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