Olsen W A, Ingelfinger F J
J Clin Invest. 1968 May;47(5):1133-42. doi: 10.1172/JCI105802.
The effect of luminal sodium on intestinal glucose absorption at a variety of glucose concentrations was studied with a segmental perfusion technique in normal subjects. Uphill glucose transport was inhibited with sodium-free perfusions with either mannitol or Tris-HCl as the osmotic replacement of sodium (P < 0.01-P < 0.001). This effect did not appear to be the result of solvent drag, as increasing net water absorption without supplying sodium to the lumen did not increase glucose absorption. Downhill glucose transport (infusion concentrations of 6.0-27.8 mmoles/liter), on the other hand, was not affected by the absence of sodium in the infusion solution. Glucose concentrations of upper intestinal fluid after normal carbohydrate meals were usually found to exceed serum concentrations; thus, downhill glucose absorption, with, at most, a very limited dependence upon intraluminal sodium concentration, may account for a significant part of normal carbohydrate absorption.
在正常受试者中，采用节段灌注技术研究了管腔钠对不同葡萄糖浓度下肠道葡萄糖吸收的影响。用甘露醇或Tris-HCl作为钠的渗透替代物进行无钠灌注时，葡萄糖的上坡转运受到抑制（P<0.01 - P<0.001）。这种效应似乎不是溶剂拖曳的结果，因为在不给管腔供应钠的情况下增加净吸水量并不会增加葡萄糖吸收。另一方面，下坡葡萄糖转运（输注浓度为6.0 - 27.8毫摩尔/升）不受输注溶液中无钠的影响。正常碳水化合物餐后上肠液中的葡萄糖浓度通常超过血清浓度；因此，下坡葡萄糖吸收对管腔内钠浓度的依赖性至多非常有限，可能占正常碳水化合物吸收的很大一部分。
