在正常人和痛风患者中，腺嘌呤 -8-13C 对甘氨酸 -15N 掺入尿尿酸的抑制作用。
Suppression of glycine-15N incorporation into urinary uric acid by adenine-8-13C in normal and gouty subjects.
作者信息
Seegmiller J E, Klinenberg J R, Miller J, Watts R W
出版信息
J Clin Invest. 1968 May;47(5):1193-203. doi: 10.1172/JCI105808.
Abstract
Adenine inhibited the de novo synthesis of purines in both normal and gouty man as shown by inhibition of the incorporation of glycine-(15)N into urinary uric acid without altering the incorporation of glycine-(15)N into urinary creatinine. The diminished purine synthesis did not result in a diminution in the 24 hr excretion of uric acid. This observation was explainable in part by the prompt conversion of adenine to uric acid. In addition to this direct conversion, adenine-8-(13)C provided a slow and prolonged contribution to urinary uric acid.A feedback inhibition of purine synthesis by nucleotides derived from adenine provides the best interpretation of these results.
摘要
腺嘌呤抑制正常人和痛风患者嘌呤的从头合成，这表现为抑制甘氨酸 -（15）N掺入尿尿酸，而不改变甘氨酸 -（15）N掺入尿肌酐。嘌呤合成减少并未导致尿酸24小时排泄量减少。这一观察结果部分可通过腺嘌呤迅速转化为尿酸来解释。除了这种直接转化外，腺嘌呤 - 8 -（13）C对尿尿酸有缓慢而持久的贡献。腺嘌呤衍生的核苷酸对嘌呤合成的反馈抑制为这些结果提供了最佳解释。
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本文引用的文献
1
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J Pharmacol Exp Ther. 1952 Jan;104(1):20-30.
2
Incorporation of glycine nitrogen into uric acid in normal and gouty man.正常人和痛风患者体内甘氨酸氮掺入尿酸的情况。
Metabolism. 1952 Jan;1(1):3-12.
3
Some factors influencing nucleic acid purine renewal in the rat.影响大鼠核酸嘌呤更新的一些因素。
Arch Biochem Biophys. 1951 Oct;33(3):436-47. doi: 10.1016/0003-9861(51)90129-4.
4
Xanthine oxidase in different species.不同物种中的黄嘌呤氧化酶。
Proc Soc Exp Biol Med. 1951 Feb;76(2):252-4. doi: 10.3181/00379727-76-18452.
5
The enzymatic spectrophotometric method for determination of uric acid.用于测定尿酸的酶促分光光度法。
J Lab Clin Med. 1959 Dec;54:903-13.
6
7
8
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J Biol Chem. 1962 Aug;237:2631-5.
9
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J Clin Invest. 1960 Mar;39(3):447-54. doi: 10.1172/JCI104057.
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