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在正常人和痛风患者中，腺嘌呤 -8-13C 对甘氨酸 -15N 掺入尿尿酸的抑制作用。

Suppression of glycine-15N incorporation into urinary uric acid by adenine-8-13C in normal and gouty subjects.

作者信息

Seegmiller J E, Klinenberg J R, Miller J, Watts R W

出版信息

J Clin Invest. 1968 May;47(5):1193-203. doi: 10.1172/JCI105808.

DOI:10.1172/JCI105808
PMID:5645862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC297271/
Abstract

Adenine inhibited the de novo synthesis of purines in both normal and gouty man as shown by inhibition of the incorporation of glycine-(15)N into urinary uric acid without altering the incorporation of glycine-(15)N into urinary creatinine. The diminished purine synthesis did not result in a diminution in the 24 hr excretion of uric acid. This observation was explainable in part by the prompt conversion of adenine to uric acid. In addition to this direct conversion, adenine-8-(13)C provided a slow and prolonged contribution to urinary uric acid.A feedback inhibition of purine synthesis by nucleotides derived from adenine provides the best interpretation of these results.

摘要

腺嘌呤抑制正常人和痛风患者嘌呤的从头合成，这表现为抑制甘氨酸 -（15）N掺入尿尿酸，而不改变甘氨酸 -（15）N掺入尿肌酐。嘌呤合成减少并未导致尿酸24小时排泄量减少。这一观察结果部分可通过腺嘌呤迅速转化为尿酸来解释。除了这种直接转化外，腺嘌呤 - 8 -（13）C对尿尿酸有缓慢而持久的贡献。腺嘌呤衍生的核苷酸对嘌呤合成的反馈抑制为这些结果提供了最佳解释。

相似文献

1
Suppression of glycine-15N incorporation into urinary uric acid by adenine-8-13C in normal and gouty subjects.在正常人和痛风患者中，腺嘌呤 -8-13C 对甘氨酸 -15N 掺入尿尿酸的抑制作用。
J Clin Invest. 1968 May;47(5):1193-203. doi: 10.1172/JCI105808.
2
The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout.给予（15N）甘氨酸后尿酸中15N的分子内分布动力学。对原发性痛风中尿酸N-（3+9）优先标记意义的重新评估。
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3
Long-term follow-up of incorporation of 15N from glycine into uric acid in gout.
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引用本文的文献

1
Clinical and biochemical aspects of uric acid overproduction.尿酸过度生成的临床与生化方面
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2
Hyperuricaemia: some biochemical aspects.高尿酸血症：一些生化方面
Proc R Soc Med. 1969 Aug;62(8):853-7. doi: 10.1177/003591576906200846.
3
Current concepts of hyperuricemia and gout.高尿酸血症与痛风的当前概念。
Calif Med. 1969 Mar;110(3):231-44.
4
Mechanism of excessive purine biosynthesis in hypoxanthine-guanine phosphoribosyltransferase deficiency.次黄嘌呤-鸟嘌呤磷酸核糖转移酶缺乏症中嘌呤生物合成过多的机制。
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5
A reappraisal of the concept of an abnormality of glutamine metabolism in primary gout.对原发性痛风中谷氨酰胺代谢异常概念的重新评估。
Trans Am Clin Climatol Assoc. 1973;84:166-82.
6
Gout and its relation to lipid metabolism. I. Serum uric acid, lipid, and lipoprotein levels in gout.痛风及其与脂质代谢的关系。I. 痛风患者的血清尿酸、脂质及脂蛋白水平
Ann Rheum Dis. 1973 Nov;32(6):501-5. doi: 10.1136/ard.32.6.501.
7
The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout.给予（15N）甘氨酸后尿酸中15N的分子内分布动力学。对原发性痛风中尿酸N-（3+9）优先标记意义的重新评估。
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Contributions of Lesch-Nyhan syndrome to the understanding of purine metabolism.莱施-奈恩综合征对嘌呤代谢理解的贡献。
J Inherit Metab Dis. 1989;12(2):184-96. doi: 10.1007/BF01800725.
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Overproduction of uric acid in hypoxanthine-guanine phosphoribosyltransferase deficiency. Contribution by impaired purine salvage.次黄嘌呤 - 鸟嘌呤磷酸核糖转移酶缺乏症中尿酸的过度产生。嘌呤补救途径受损的影响。
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J Clin Invest. 1976 Feb;57(2):308-18. doi: 10.1172/JCI108282.

本文引用的文献

1
Adenine intoxication in relation to in vivo formation and deposition of 2,8-dioxyadenine in renal tubules.腺嘌呤中毒与肾小管中2,8 - 二氧腺嘌呤的体内形成和沉积的关系。
J Pharmacol Exp Ther. 1952 Jan;104(1):20-30.
2
Incorporation of glycine nitrogen into uric acid in normal and gouty man.正常人和痛风患者体内甘氨酸氮掺入尿酸的情况。
Metabolism. 1952 Jan;1(1):3-12.
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Some factors influencing nucleic acid purine renewal in the rat.影响大鼠核酸嘌呤更新的一些因素。
Arch Biochem Biophys. 1951 Oct;33(3):436-47. doi: 10.1016/0003-9861(51)90129-4.
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Xanthine oxidase in different species.不同物种中的黄嘌呤氧化酶。
Proc Soc Exp Biol Med. 1951 Feb;76(2):252-4. doi: 10.3181/00379727-76-18452.
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The enzymatic spectrophotometric method for determination of uric acid.用于测定尿酸的酶促分光光度法。
J Lab Clin Med. 1959 Dec;54:903-13.
6
REGULATION OF PURINE RIBONUCLEOTIDE SYNTHESIS BY END PRODUCT INHIBITION. THE EFFECT OF ADENINE AND GUANINE RIBONUCLEOTIDES ON THE 5'-PHOSPHORIBOSYL-PYROPHOSPHATE AMIDOTRANSFERASE OF AEROBACTER AEROGENES.终产物抑制对嘌呤核糖核苷酸合成的调节。腺嘌呤和鸟嘌呤核糖核苷酸对产气气杆菌5'-磷酸核糖焦磷酸酰胺转移酶的影响。
J Biol Chem. 1965 Jan;240:358-65.
7
THE ENZYMOLOGY OF FEEDBACK INHIBITION OF GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE BY PURINE RIBONUCLEOTIDES.嘌呤核糖核苷酸对谷氨酰胺磷酸核糖焦磷酸酰胺转移酶反馈抑制的酶学研究
J Biol Chem. 1964 Aug;239:2570-9.
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Feedback inhibition of purine biosynthesis in ascites tumor cells.腹水肿瘤细胞中嘌呤生物合成的反馈抑制
J Biol Chem. 1962 Aug;237:2631-5.
9
Intramolecular distribution of uric acid-N15 after administration of glycine-N15 and ammonium-N15 chloride to goury and non-goury subjects.向痛风患者和非痛风患者施用甘氨酸-N15和氯化铵-N15后尿酸-N15的分子内分布。
J Clin Invest. 1962 Mar;41(3):623-36. doi: 10.1172/JCI104518.
10
Suppression of uric acid synthesis in the gouty human by the use of 6-diazo-5-oxo-L-norleucine.使用6-重氮-5-氧代-L-正亮氨酸对痛风患者尿酸合成的抑制作用。
J Clin Invest. 1960 Mar;39(3):447-54. doi: 10.1172/JCI104057.