Telesnina G N, Bartoshevich Iu E, Mironov V A, Sazykin Iu O, Zviagil'skaia R A
Antibiotiki. 1978 Feb;23(2):109-14.
Energy parameters of the two strains of the inperfect fungus Fusidium coccineum with different levels of antibiotic production were studied comparatively. It was shown that the respiration activity of the both strains was almost completely suppressed by KCN+ salycyl hydroxomate. It provided a supposition that the respiration activity was almost selectively connected with the mitochondria. The analysis of the energy parameters and especially the efficiency of the substrate consumption indicated that the system of oxidative phospholiration was dominant in the energy supply in both the strains. The differences between the strains were observed in the growth rate and the level of KCN-stable respiration. A change in the respiration of the active strain to the alternative KCN-stable path was observed by the end of the 6-8 day fermentation process when significant amounts of fusidin accumulated in the fermentation broth. Correlation between the level of KCN-stability and the antibiotic production was found.
对两种产抗生素水平不同的不完全真菌绯色镰刀菌菌株的能量参数进行了比较研究。结果表明，KCN + 水杨基氧肟酸几乎完全抑制了两种菌株的呼吸活性。这表明呼吸活性几乎与线粒体选择性相关。能量参数分析，尤其是底物消耗效率表明，氧化磷酸化系统在两种菌株的能量供应中占主导地位。在生长速率和KCN稳定呼吸水平上观察到菌株之间的差异。在6 - 8天发酵过程结束时，当发酵液中积累了大量夫西地素时，观察到活性菌株的呼吸转变为替代的KCN稳定途径。发现了KCN稳定性水平与抗生素生产之间的相关性。
