Penzikova G A, Sepanova N E, Levitov M M
Antibiotiki. 1977 Jan;22(1):29-32.
The physiological features of Fusidium coccineum, strain 257 A, an organism producing fusidin were studied. It was found that increased concentrations of the carbon sources in the medium stimulated production of fusidin, while an increase in the content of various forms of nitrogen differently affected the level of the antibiotic viosynthesis: high concentrations of the amino acid-peptide form of nitrogen of corn-steep liquor decreased, while the protein form of nitrogen was associated with consumption of the significant part of carbon in the medium for formation of the fungus mycelium. Therefore, the concentration of the easily mobilizing forms of nitrogen may be considered as a regulator of the growth process of F. coccineum 257 A and production of fusidin by it.
对产生夫西地酸的有机体——深红梭链孢菌257A菌株的生理特性进行了研究。结果发现，培养基中碳源浓度的增加会刺激夫西地酸的产生，而各种形式氮含量的增加对抗生素生物合成水平的影响各不相同：玉米浆中高浓度的氨基酸 - 肽形式的氮会降低抗生素产量，而蛋白质形式的氮则与培养基中大量碳用于形成真菌菌丝体有关。因此，易动员形式的氮的浓度可被视为深红梭链孢菌257A生长过程及其夫西地酸产生的调节剂。
