Alexander J C, Silverman N A, Chretien P B
JAMA. 1976 May 3;235(18):1975-9.
Serum carcinoembryonic antigen (CEA) levels were determined by the Hansen-Z-gel technique in 276 healthy volunteers, of whom 154 were smokers and 122 nonsmokers. The mean CEA level was significantly higher in smokers (2.7 ng/ml) than in nonsmokers (1.9 ng/ml) (P less than .001), and a significantly higher percentage of smokers had elevated CEA levels (P less than .05). In both groups, CEA levels were directly related to age. Seventy-six of the 154 smokers who entered the study ceased smoking. Their CEA levels were determined at one, three, and six months after cessation of smoking. Within three months after cessation, elevated CEA levels declined to within the range of nonsmokers and did not appear to be influenced by previous smoking habits. Both age and smoking history must be considered for accurate evaluation of CEA levels. A reappraisal of the diseases associated with elevated CEA levels that considers the influence of age and smoking may invalidate some of the correlations previously reported.
采用汉森 - Z凝胶技术测定了276名健康志愿者的血清癌胚抗原（CEA）水平，其中154名是吸烟者，122名是非吸烟者。吸烟者的平均CEA水平（2.7 ng/ml）显著高于非吸烟者（1.9 ng/ml）（P <.001），且吸烟者中CEA水平升高的百分比显著更高（P <.05）。在两组中，CEA水平均与年龄直接相关。参与研究的154名吸烟者中有76人戒烟。在戒烟后的1个月、3个月和6个月测定了他们的CEA水平。戒烟后3个月内，升高的CEA水平降至非吸烟者范围内，且似乎不受既往吸烟习惯的影响。为准确评估CEA水平，必须同时考虑年龄和吸烟史。重新评估与CEA水平升高相关的疾病时，若考虑年龄和吸烟的影响，可能会使先前报道的一些相关性无效。
