正常吸烟者和非吸烟者肺衬液中癌胚抗原的定量分析。

Quantitation of carcinoembryonic antigen in the lung lining fluid of normal smokers and nonsmokers.

作者信息

Merrill W W, Goodman M, Matthay R A, Naegel G P, Vandevoorde J P, Myl A D, Reynolds H Y

出版信息

Am Rev Respir Dis. 1981 Jan;123(1):29-31. doi: 10.1164/arrd.1981.123.1.29.

DOI:10.1164/arrd.1981.123.1.29

Abstract

Bronchoalveolar lavage was performed in 47 volunteers: 19 nonsmokers and 28 smokers. Total protein, albumin, immunoglobulins G and A, and carcinoembryonic antigen (CEA) were measured in the concentrated lavage effluent. Although a significant increase (p < 0.001) in the ratio of CEA to total protein recovered from the group of smokers was found, this increase primarily reflected the greater increase that occurred in a subgroup of 7 smokers. However, the increases in lavage CEA correlated weakly (p = 0.096) with smoking history in pack-years, and not at all with plasma CEA concentrations. Results regarding the number of cells recovered and immunoglobulin-to-albumin concentration ratios in these subjects were similar to those reported by others. Thus, CEA was increased in the lavage fluid of a subgroup of otherwise normal young smokers. It is possible that CEA might serve as a useful indicator of future airway disease in certain young smokers.

摘要

对47名志愿者进行了支气管肺泡灌洗：19名不吸烟者和28名吸烟者。对浓缩的灌洗流出液中的总蛋白、白蛋白、免疫球蛋白G和A以及癌胚抗原（CEA）进行了测量。虽然发现吸烟者组中回收的CEA与总蛋白的比率有显著增加（p < 0.001），但这种增加主要反映了7名吸烟者亚组中出现的更大增加。然而，灌洗CEA的增加与吸烟史（以包年计）的相关性较弱（p = 0.096），与血浆CEA浓度完全无关。这些受试者中回收的细胞数量以及免疫球蛋白与白蛋白浓度比的结果与其他人报告的结果相似。因此，在其他方面正常的年轻吸烟者亚组的灌洗液体中CEA增加。在某些年轻吸烟者中，CEA有可能作为未来气道疾病的有用指标。