甲状旁腺激素和维生素D3代谢产物对胚胎十二指肠体外合成钙结合蛋白的影响。
The effect of parathyroid hormone and vitamin D3 metabolites on CaBP synthesis by embryonic duodenum, in vitro.
作者信息
Parkes C O, Reynolds J J
出版信息
Horm Metab Res. 1978 Jan;10(1):75-7. doi: 10.1055/s-0028-1093486.
PMID:564862
Abstract
Embryonic chick duodena were incubated, in vitro, for two days in the presence of vitamin D analogues and metabolites and the ability of PTH to potentiate the vitamin-D-dependent synthesis of CaBP measured. PTH potentiated CaBP synthesis in the presence of vitamin D3, 25-OH-D3, 1 alpha-OH-D3, DHT, and 1,25(OH)2D3. The synthesis of CaBP was directly related to the log of the meddium PTH concentration over the range 1 x 10(-8) M to 5 x 10(-7) M.
摘要
将鸡胚十二指肠在体外与维生素D类似物和代谢产物一起孵育两天，然后检测甲状旁腺激素（PTH）增强维生素D依赖性钙结合蛋白（CaBP）合成的能力。在维生素D3、25-羟基维生素D3、1α-羟基维生素D3、双氢睾酮（DHT）和1,25-二羟基维生素D3存在的情况下，PTH增强了CaBP的合成。在1×10⁻⁸ M至5×10⁻⁷ M的范围内，CaBP的合成与培养基中PTH浓度的对数直接相关。
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