甲状旁腺激素（PTH）和1,25-二羟维生素D3（1,25(OH)2D3）对红系前体细胞RNA和血红素合成的影响。
The effect of parathyroid hormone (PTH) and 1,25 dihydroxy vitamin D3 (1,25(OH)2D3) on RNA and heme synthesis by erythroid precursors.
作者信息
Levi J, Zevin D, Bessler H, Djaldetti M
出版信息
Proc Eur Dial Transplant Assoc. 1980;17:603-7.
PMID:6165984
Abstract
PTH was shown to stimulate RNA and heme synthesis in 12-13 days embryonic mouse liver erythroid cells, thus expressing an erythropoietin-like effect. Incubation of erythroid precursors with 1,25(OH)2D3 had no effect on heme synthesis, and increased the RNA synthesis only slightly, thus showing no enhancement effect of 1,25(OH)2D3 on the PTH stimulating effect on erythropoiesis.
摘要
甲状旁腺激素（PTH）被证明可刺激12 - 13日龄胚胎小鼠肝脏红系细胞中的RNA和血红素合成，从而表现出类似促红细胞生成素的作用。用1,25 - 二羟维生素D3（1,25(OH)2D3）孵育红系前体细胞对血红素合成没有影响，仅略微增加了RNA合成，因此表明1,25(OH)2D3对PTH刺激红细胞生成的作用没有增强效果。
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