Sonneborn H H, De Weck A L, Toffler O
Infusionsther Klin Ernahr. 1978 Feb;5(1):41-9.
The immune response of rabbits and guinea pigs to gelatin and to three commercial plasma substitutes based on gelatin (oxypolygelatin [OPG], di-isocyanate cross-linked gelatin [DCG], modified fluid gelatin [MFG]) has been reevaluated. Passive hemagglutination, passive cutaneous anaphylaxis and active anaphylaxis have been used to detect the response of animals immunized in complete Fruend's adjuvant or in aluminium hydroxide. Marked immune responses were observed with DCG and MFG which were to a large extent specific for the immunizing antigen (i.e. the corresponding chemically modified gelatin). Gelatin and OPG induced weak responses. In contrast to DCG and MFG in systemic anaphylactic shock experiments no anaphylactic shock could be elicited with gelatin and OPG. A limited series of immunizations in guinea pigs of various strains demonstrated that responses to weak immunogens, such as modified gelatins, are markedly influenced by genetic factors.
已重新评估家兔和豚鼠对明胶以及三种基于明胶的商用血浆代用品（氧化聚明胶[OPG]、二异氰酸酯交联明胶[DCG]、改良液体明胶[MFG]）的免疫反应。采用被动血凝反应、被动皮肤过敏反应和主动过敏反应来检测在完全弗氏佐剂或氢氧化铝中免疫的动物的反应。观察到DCG和MFG有明显的免疫反应，在很大程度上对免疫抗原（即相应的化学修饰明胶）具有特异性。明胶和OPG诱导的反应较弱。与DCG和MFG相反，在全身性过敏休克实验中，明胶和OPG不会引发过敏休克。在不同品系豚鼠中进行的一系列有限免疫实验表明，对弱免疫原（如修饰明胶）的反应受到遗传因素的显著影响。
