Mohr J P, Pessin M S, Finkelstein S, Funkenstein H H, Duncan G W, Davis K R
Neurology. 1978 Apr;28(4):311-24. doi: 10.1212/wnl.28.4.311.
The speech disturbance resulting from infarction limited to the Broca area has been delineated; it differs from the speech disorder called Broca aphasia, which results from damage extending far outside the Broca area. Nor does Broca area infarction cause Broca aphasia. The lesions in 20 cases observed since 1972 were documented by autopsy, computerized tomography, or arteriogram; the autopsy records from the Massachusetts General hospital for the past 20 years and the published cases since 1820 were also reviewed. The findings suggest that infarction affecting the Broca area and its immediate environs, even deep into the brain, causes a mutism that is replaced by rapidly improving dyspraxic and effortful articulation, but that no significant distrubance in language function persists. The more complex syndrome traditionally referred to as Broca aphasia, including Broca's original case, is characterized by protracted mutism, verbal stereotypes, and agrammatism. It is associated with a considerably larger infarct which encompasses the operculum, including the Broca area, insula, and adjacent cerebrum, in the territory supplied by the upper division of the left middle cerebral artery.
局限于布洛卡区梗死所致的言语障碍已被明确；它不同于所谓的布洛卡失语症，后者是由远超出布洛卡区的损伤所致。布洛卡区梗死也不会导致布洛卡失语症。自1972年以来观察到的20例病例的病变通过尸检、计算机断层扫描或血管造影记录；还查阅了过去20年马萨诸塞州总医院的尸检记录以及自1820年以来发表的病例。研究结果表明，影响布洛卡区及其紧邻区域甚至深入脑内的梗死会导致缄默，随后迅速改善为言语失用和费力的发音，但语言功能并无持续的明显障碍。传统上称为布洛卡失语症的更复杂综合征，包括布洛卡最初的病例，其特征为持续性缄默、言语刻板症和语法缺失。它与相当大的梗死灶相关，该梗死灶累及岛盖，包括布洛卡区、岛叶和邻近大脑，位于左大脑中动脉上部分支供血区域。
