Heintze K, Petersen K U, Busch L
Pflugers Arch. 1978 Jan 31;373(1):9-13. doi: 10.1007/BF00581142.
The influence of hydrostatic pressure elevation on fluid absorption by the isolated guinea pig gallbladder was determined following addition of various smooth muscle spasmogens to the serosal bathing medium. Acetylcholine, prostaglandin E1 and ouabain increased intraluminal pressure from about 4 cm H2O to 13 cm H2O. The pressure increase was associated with a marked but transient stimulation in fluid transfer. The same phenomenon was observed following an increase in hydrostatic pressure by addition of Ringer's solution to the gallbladder lumen. Evidence is presented to support the hypothesis that this phenomenon represents the extrusion of an edema from the gallbladder wall. Two observations favour this explanation: 1. The wet weights of gallbladder subjected to high intraluminal hydrostatic pressure were only one third of those at low pressure. 2. Microscopic examination of the wall of gallbladders at low pressure showed a marked submucosal edema.
在向浆膜侧浴液中添加各种平滑肌痉挛剂后，测定了静水压力升高对离体豚鼠胆囊液体吸收的影响。乙酰胆碱、前列腺素E1和哇巴因使腔内压力从约4 cm H₂O升高至13 cm H₂O。压力升高与液体转运的显著但短暂的刺激相关。在向胆囊腔内添加林格氏液使静水压力升高后，也观察到了同样的现象。有证据支持这一假说，即该现象代表胆囊壁水肿的排出。有两点观察结果支持这一解释：1. 承受高腔内静水压力的胆囊湿重仅为低压力时的三分之一。2. 对低压力胆囊壁的显微镜检查显示有明显的黏膜下水肿。
