哺乳未能将免疫传递给同基因大鼠肉瘤。
Failure of suckling to transfer immunity to a syngeneic rat sarcoma.
作者信息
Eccles S A, Alexander P
出版信息
Br J Cancer. 1978 Mar;37(3):458-60. doi: 10.1038/bjc.1978.66.
Abstract
Young born to and suckled by mothers rendered immune to a syngeneic sarcoma showed no acquired resistance to challenge with tumour. Whilst other workers had found that allograft immunity could be transferred by milk, we conclude (1) that lymphocytes present in the milk cannot transfer immunity to tumour-specific antigens when absorbed by suckling, and (2) that transfer of maternal immunoglobulins either pre- or postnatally also does not protect against s.c. inoculated tumour.
摘要
由对同基因肉瘤产生免疫的母亲所生并由其哺乳的幼崽，对肿瘤攻击未表现出获得性抗性。虽然其他研究人员发现同种异体移植免疫可通过乳汁传递，但我们得出结论：（1）乳汁中的淋巴细胞在被幼崽吸收时，不能将对肿瘤特异性抗原的免疫传递给幼崽；（2）产前或产后母体免疫球蛋白的传递也不能保护幼崽免受皮下接种肿瘤的侵害。
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