对自然发生的大鼠肉瘤的免疫反应。
Immune responses to naturally occurring rat sarcomas.
作者信息
Embleton M J, Middle J G
出版信息
Br J Cancer. 1981 Jan;43(1):44-52. doi: 10.1038/bjc.1981.6.
Abstract
Attempts were made to induce immunity to 5 spontaneous rat sarcomas transplanted into syngeneic recipients. Rats were immunized by surgical removal of growing tumour transplants or by treatment with attenuated tumour, followed by challenge with tumour cells in suspension. Two tumours wee apparently not immunogenic, but a low level of immunity was induced against 2, and weak evidence of immunity was observed with another. Induced immunity was individually specific rather than cross-reactive. It is concluded that, contrary to some reports, some spontaneous animal tumours are immunogenic in the strain of origin.
摘要
研究人员尝试诱导对移植到同基因受体体内的5种自发性大鼠肉瘤产生免疫。通过手术切除生长中的肿瘤移植体或用减毒肿瘤进行治疗，随后用悬浮的肿瘤细胞进行攻击，对大鼠进行免疫。有两种肿瘤显然没有免疫原性，但对另外两种肿瘤诱导出了低水平的免疫，对另一种肿瘤观察到了微弱的免疫证据。诱导的免疫具有个体特异性而非交叉反应性。得出的结论是，与一些报道相反，一些自发性动物肿瘤在其起源品系中具有免疫原性。
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本文引用的文献
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Int J Cancer. 1978 Oct 15;22(4):426-32. doi: 10.1002/ijc.2910220410.
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