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相似文献

1
A renally active substance from heart muscle and from blood.一种来自心肌和血液的具有肾脏活性的物质。
J Physiol. 1968 May;196(1):101-9. doi: 10.1113/jphysiol.1968.sp008497.
2
The separation of renal activity from lung and from the venous effluent from perfused lungs.肾脏活动与肺部以及灌注肺静脉流出物的分离。
J Physiol. 1971 Feb;212(3):719-31. doi: 10.1113/jphysiol.1971.sp009352.
3
The isolation of a renally active substance from arterial blood.从动脉血中分离出一种具有肾脏活性的物质。
J Physiol. 1972 May;223(1):49-57. doi: 10.1113/jphysiol.1972.sp009833.
4
Hormonal actions of the heart and of lungs on the isolated kidney.心脏和肺对离体肾脏的激素作用。
J Physiol. 1967 Dec;193(3):661-9. doi: 10.1113/jphysiol.1967.sp008386.
5
Studies on action of hypotensive substance from renal medulla on the heart and smooth muscle.肾髓质降压物质对心脏和平滑肌作用的研究。
Bull Acad Pol Sci Biol. 1968;16(12):787-90.
6
Cardiotonic steroids extracted from rabbit uterine tissue and amnionic fluid.从兔子宫组织和羊水提取的强心甾体类化合物。
Proc West Pharmacol Soc. 1989;32:19-22.
7
The formation of a renally active peptide by cat lungs from gamma-globulin in vitro and the plasma concentrations of this peptide, in vivo.猫肺在体外由γ球蛋白形成具有肾脏活性的肽以及该肽在体内的血浆浓度。
J Physiol. 1972 Jul;224(1):187-94. doi: 10.1113/jphysiol.1972.sp009888.
8
The isolation of a substance very closely resembling the 18-monoacetate of D-aldosterone from the venous blood of activated muscle and from contracting muscle.从活化肌肉的静脉血和收缩肌肉中分离出一种与D-醛固酮18-单乙酸酯非常相似的物质。
J Physiol. 1969 Oct;204(2):435-42. doi: 10.1113/jphysiol.1969.sp008922.
9
The release of a renally active substance by perfused rat hearts.灌注大鼠心脏释放一种具有肾脏活性的物质。
J Physiol. 1971 Feb;212(3):733-8. doi: 10.1113/jphysiol.1971.sp009353.
10
Changes in the flow and composition of the urine induced by the 18 monoacetate of D-aldosterone, in cats.猫体内由D - 醛固酮18 - 单乙酸酯引起的尿液流量和成分变化。
J Physiol. 1969 Jun;202(3):671-82. doi: 10.1113/jphysiol.1969.sp008834.

引用本文的文献

1
The isolation of a substance very closely resembling the 18-monoacetate of D-aldosterone from the venous blood of activated muscle and from contracting muscle.从活化肌肉的静脉血和收缩肌肉中分离出一种与D-醛固酮18-单乙酸酯非常相似的物质。
J Physiol. 1969 Oct;204(2):435-42. doi: 10.1113/jphysiol.1969.sp008922.
2
Changes in the flow and composition of the urine induced by the 18 monoacetate of D-aldosterone, in cats.猫体内由D - 醛固酮18 - 单乙酸酯引起的尿液流量和成分变化。
J Physiol. 1969 Jun;202(3):671-82. doi: 10.1113/jphysiol.1969.sp008834.
3
Factors controlling the secretion of a substance biologically resembling the 18-monoacetate of D-aldosterone by heart muscle.控制心肌分泌一种生物学上类似于D-醛固酮18-单乙酸酯物质的因素。
J Physiol. 1970 Oct;210(3):717-25. doi: 10.1113/jphysiol.1970.sp009237.
4
The influence of heart rate on the secretion of a substance closely resembling the 18-monoacetate of D-aldosterone by the hearts of cats under chloralose anaesthesia.氯醛糖麻醉下猫心脏心率对一种与D-醛固酮18-单乙酸酯极为相似的物质分泌的影响。
J Physiol. 1970 May;208(1):21-32. doi: 10.1113/jphysiol.1970.sp009103.
5
The isolation of a renally active substance from arterial blood.从动脉血中分离出一种具有肾脏活性的物质。
J Physiol. 1972 May;223(1):49-57. doi: 10.1113/jphysiol.1972.sp009833.
6
The separation of renal activity from lung and from the venous effluent from perfused lungs.肾脏活动与肺部以及灌注肺静脉流出物的分离。
J Physiol. 1971 Feb;212(3):719-31. doi: 10.1113/jphysiol.1971.sp009352.
7
The formation of a renally active peptide by cat lungs from gamma-globulin in vitro and the plasma concentrations of this peptide, in vivo.猫肺在体外由γ球蛋白形成具有肾脏活性的肽以及该肽在体内的血浆浓度。
J Physiol. 1972 Jul;224(1):187-94. doi: 10.1113/jphysiol.1972.sp009888.

本文引用的文献

1
Hormonal actions of the heart and of lungs on the isolated kidney.心脏和肺对离体肾脏的激素作用。
J Physiol. 1967 Dec;193(3):661-9. doi: 10.1113/jphysiol.1967.sp008386.
2
The influence of the polar anastomotic vessels on autoregulation and the urinary excretion of water and sodium by perfused cat kidneys.极性吻合血管对灌注猫肾的自身调节以及水和钠尿排泄的影响。
J Physiol. 1967 Dec;193(3):649-60. doi: 10.1113/jphysiol.1967.sp008385.
3
The estimation of adrenaline and allied substances in blood.血液中肾上腺素及相关物质的测定
J Physiol. 1949 Jun 15;108(4):467-81. doi: 10.1113/jphysiol.1949.sp004350.
4
THIN-LAYER CHROMATOGRAPHIC SYSTEMS FOR ADRENAL CORTICOSTEROIDS.用于肾上腺皮质类固醇的薄层色谱系统
Anal Biochem. 1964 Jun;8:192-9. doi: 10.1016/0003-2697(64)90046-6.
5
Effects of brain stem lesions on aldosterone and cortisol secretion.脑干病变对醛固酮和皮质醇分泌的影响。
Endocrinology. 1962 Apr;70:556-66. doi: 10.1210/endo-70-4-556.
6
Actions and interactions of aldosterone monoacetate and neurohypophysial hormones on the isolated cat kidney.单醋酸醛固酮与神经垂体激素对离体猫肾的作用及相互作用
J Physiol. 1960 Jul;152(2):206-19. doi: 10.1113/jphysiol.1960.sp006482.
7
The transmitter released by stimulation of the bronchial sympathetic nerves of cats.由刺激猫的支气管交感神经释放的递质。
Br J Pharmacol Chemother. 1957 Mar;12(1):86-96. doi: 10.1111/j.1476-5381.1957.tb01367.x.
8
The physiological basis for a method of assaying aldosterone in extracts of human urine.一种测定人尿提取物中醛固酮方法的生理学基础。
J Clin Invest. 1955 Sep;34(9):1410-6. doi: 10.1172/JCI103190.
9
Species differences in adrenocortical secretion.肾上腺皮质分泌的物种差异。
J Endocrinol. 1953 Jan;9(1):95-100. doi: 10.1677/joe.0.0090095.
10
Perfusion of cat kidneys from heart-lung circuits.使用心肺循环装置对猫肾进行灌注。
Proc Soc Exp Biol Med. 1966 Mar;121(3):937-41. doi: 10.3181/00379727-121-30929.

一种来自心肌和血液的具有肾脏活性的物质。

A renally active substance from heart muscle and from blood.

作者信息

Ilett K F, Lockett M F

出版信息

J Physiol. 1968 May;196(1):101-9. doi: 10.1113/jphysiol.1968.sp008497.

DOI:10.1113/jphysiol.1968.sp008497
PMID:5653880
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1351737/
Abstract
  1. A steroid-like compound has been isolated from cat heart muscle by thin-layer chromatography.2. This compound has been characterized by measurement of its R(F) values in two solvent systems.3. No similar substance could be detected in the 1 hr venous outputs of cat adrenals.4. It could not be detected in heart-lung circuit blood when the heart had been perfusing for 1(1/4)-1(1/2) hr at constant venous input and peripheral resistance. The compound was however extractable from the circuit blood 10-15 min after reduction in venous input.5. The actions of this compound on the isolated kidney resemble those of aldosterone but are of much shorter latency.6. The heart substance differs from aldosterone in R(F) values and has more than 10 times the renal activity of aldosterone when the two substances are equated (visually) for ability to reduce blue tetrazolium.
摘要

  1. 已通过薄层色谱法从猫心肌中分离出一种类固醇样化合物。

  2. 该化合物已通过测量其在两种溶剂系统中的R(F)值进行了表征。

  3. 在猫肾上腺1小时的静脉输出中未检测到类似物质。

  4. 当心脏在恒定静脉输入和外周阻力下灌注1(1/4)-1(1/2)小时时，在心肺循环血液中未检测到该物质。然而，在静脉输入减少10-15分钟后，该化合物可从循环血液中提取出来。

  5. 该化合物对离体肾脏的作用类似于醛固酮，但潜伏期要短得多。

  6. 心脏物质在R(F)值上与醛固酮不同，当两种物质在使蓝色四氮唑还原的能力方面（视觉上）相等时，其对肾脏的活性是醛固酮的10倍以上。