Enstrom J E, Operskalski E A
Neurology. 1978 May;28(5):434-8. doi: 10.1212/wnl.28.5.434.
The 2,500,000 Spanish-surnamed white Californians have an age-adjusted multiple sclerosis death rate of 0.27 per 100,000 based on 48 MS deaths from 1966 through 1975. This compares with a rate of 0.83 for other white Californians and 0.75 for all Californians, suggesting that the MS death rate in California is due to genetic or local environmental causes. However, the 620,000 foreign-born Spanish-surnamed white Califorians have the extremely low MS death rate of 0.07, which is one-sixth the rate of 0.42 for the 1.330,000 Spanish-surnamed whites born in California. These data, by contrast with the first set, seem to indicate that environmental factors associated with place of birth are of primary importance. These findings suggest that Spanish-Americans as a whole have an MS death rate that is among the lowest of all subpopulation in the United States and that they offer additional opportunities for studying the etiology of multiple sclerosis.
根据1966年至1975年间48例多发性硬化症死亡病例，250万西班牙裔姓氏的加利福尼亚白人的年龄调整后多发性硬化症死亡率为每10万人0.27例。相比之下，其他加利福尼亚白人的死亡率为0.83，所有加利福尼亚人的死亡率为0.75，这表明加利福尼亚的多发性硬化症死亡率是由遗传或当地环境因素导致的。然而，62万出生在国外的西班牙裔姓氏的加利福尼亚白人的多发性硬化症死亡率极低，为0.07，仅为133万出生在加利福尼亚的西班牙裔姓氏白人死亡率0.42的六分之一。与第一组数据相比，这些数据似乎表明与出生地相关的环境因素至关重要。这些发现表明，西班牙裔美国人总体上的多发性硬化症死亡率是美国所有亚人群中最低的，并且他们为研究多发性硬化症的病因提供了更多机会。
