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无类固醇条件下大鼠乳腺的体外分化

Rat mammary gland differentiation in vitro in the absence of steroids.

作者信息

Dilley W G, Nandi S

出版信息

Science. 1968 Jul 5;161(3836):59-60. doi: 10.1126/science.161.3836.59.

DOI:10.1126/science.161.3836.59
PMID:5655265
Abstract

Mammary glands from several strains of immature female rats will form small lobules of alveoli when cultured in chemically defined media lacking steroid hormones but containing insulin and prolactin. The degree of lobulo-alveolar differentiation is increased if estradiol, progesterone, and aldosterone are also included in the culture media.

摘要

在缺乏类固醇激素但含有胰岛素和催乳素的化学成分明确的培养基中培养时,几只未成熟雌性大鼠品系的乳腺会形成小的腺泡小叶。如果培养基中还加入雌二醇、孕酮和醛固酮,小叶-腺泡分化程度会增加。

相似文献

1
Rat mammary gland differentiation in vitro in the absence of steroids.无类固醇条件下大鼠乳腺的体外分化
Science. 1968 Jul 5;161(3836):59-60. doi: 10.1126/science.161.3836.59.
2
Influence of hormones on lobulo-alveolar differentiation of mouse mammary glands in vitro.激素对体外培养的小鼠乳腺小叶-腺泡分化的影响。
J Endocrinol. 1966 Aug;35(4):331-40. doi: 10.1677/joe.0.0350331.
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Strain differences in response of the mouse mammary gland to hormones in vitro.小鼠乳腺在体外对激素反应的品系差异。
J Natl Cancer Inst. 1970 Oct;45(4):657-75.
4
Steroid structural requirements for mammary gland differentiation in vitro.体外乳腺分化的类固醇结构要求
Endocrinology. 1967 Jun;80(6):1139-42. doi: 10.1210/endo-80-6-1139.
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Relationship of mitosis to alveolar development in the rat mammary gland.大鼠乳腺有丝分裂与肺泡发育的关系。
J Endocrinol. 1971 Jul;50(3):501-5. doi: 10.1677/joe.0.0500501.
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Effects of steroid hormone treatment on mammary development in prepubertal heifers.类固醇激素处理对青春期前小母牛乳腺发育的影响。
Domest Anim Endocrinol. 1998 Nov;15(6):489-98. doi: 10.1016/s0739-7240(98)00037-x.
7
Action of growth-promoting hormones on macromolecular biosynthesis during lobulo-alveolar development of the entire mammary gland in organ culture.
Acta Endocrinol (Copenh). 1975 Nov;80(3):501-16. doi: 10.1530/acta.0.0800501.
8
Effects of perinatal estrogen on mouse mammary response to corticoids in vitro.
In Vitro. 1977 Aug;13(8):477-83. doi: 10.1007/BF02615139.
9
Estrogen affects development of alveolar structures in whole-organ culture of mouse mammary glands.雌激素对小鼠乳腺全器官培养中腺泡结构的发育有影响。
Biochem Biophys Res Commun. 1997 Mar 17;232(2):340-4. doi: 10.1006/bbrc.1997.6283.
10
Effect of perinatal oestrogen on the pretreatment required for mouse mammary lobular formation in vitro.围产期雌激素对小鼠乳腺小叶体外形成所需预处理的影响。
J Endocrinol. 1978 Apr;77(1):1-10. doi: 10.1677/joe.0.0770001.

引用本文的文献

1
Hormones and mammary carcinogenesis in mice, rats, and humans: a unifying hypothesis.小鼠、大鼠和人类中的激素与乳腺癌发生:一个统一假说。
Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3650-7. doi: 10.1073/pnas.92.9.3650.
2
Whole mammary gland organ culture: selection of appropriate gland.全乳腺器官培养:合适腺体的选择。
In Vitro. 1973 Sep-Oct;9(2):129-33. doi: 10.1007/BF02616011.
3
Maintenance of normal human breast organoids within rat mammary fat pads in organ culture.
Virchows Arch A Pathol Anat Histopathol. 1987;410(6):495-500. doi: 10.1007/BF00781684.
4
Growth control and differentiation in mammary epithelial cells.乳腺上皮细胞的生长控制与分化
Environ Health Perspect. 1989 Mar;80:85-99. doi: 10.1289/ehp.898085.