植物血凝素对免疫反应的影响。
Effect of phytohaemagglutinin on the immune response.
作者信息
Jasin H E, Ziff M
出版信息
Immunology. 1968 May;14(5):735-43.
The effect of phytohaemagglutinin (PHA) on the immune response of mice and rats has been investigated. A marked depression of anti-sheep erythrocyte agglutinin titres was found in both species following primary immunization. The decrease in titre was due to a depression of 2-mercaptoethanol resistant antibodies. The treated rats also developed antibodies against the haemagglutinating component of PHA. PHA produced no depression of the delayed hypersensitivity response to tuberculin; nor did it suppress adjuvant arthritis in the rat. Histological examination of the lymphoid organs of PHA treated mice revealed reactive hyperplasia. Similar histological changes were seen in mice injected at the same time with a strong antigen such as horse ferritin. The depressive effect of PHA on IgG antibody formation and the absence of an effect on IgM antibody formation, delayed hypersensitivity, and adjuvant arthritis are discussed.
已对植物血凝素（PHA）对小鼠和大鼠免疫反应的作用进行了研究。在初次免疫后，发现这两个物种的抗绵羊红细胞凝集素滴度均显著降低。滴度降低是由于对2-巯基乙醇有抗性的抗体减少所致。经处理的大鼠还产生了针对PHA血凝成分的抗体。PHA对结核菌素的迟发型超敏反应没有抑制作用；它也不抑制大鼠的佐剂性关节炎。对经PHA处理的小鼠的淋巴器官进行组织学检查发现有反应性增生。在同时注射强抗原如马铁蛋白的小鼠中也观察到了类似的组织学变化。讨论了PHA对IgG抗体形成的抑制作用以及对IgM抗体形成、迟发型超敏反应和佐剂性关节炎无作用的情况。
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