Marshall J F
Pharmacol Biochem Behav. 1978 Mar;8(3):281-6. doi: 10.1016/0091-3057(78)90317-9.
Rats that were made diabetic by the subcutaneous injection of alloxan monohydrate were found to be resistant to the anorexic action of d-amphetamine. This resistance to amphetamine anorexia did not appear attributable to an increased hunger motivation of the diabetic rats, but rather seemed due to a diminished action of the drug in alloxan-injected animals. This conclusion was supported by further experiments indicating that alloxan-injected rats show diminished locomotor activity and stereotyped behavior following amphetamine administration. Furthermore, the amphetamine resistance appears to be the result of the diabetic state, since amphetamine-induced stereotyped behavior could be reinstated in alloxan-injected rats by the administration of protamine zinc insulin for ten days. The results of these investigations suggest that there exists an altered central nervous system response to d-amphetamine in the diabetic rat. These possibility of an abnormal functioning of central catecholamine-containing neurons in such animals is discussed.
通过皮下注射一水合四氧嘧啶制成糖尿病的大鼠被发现对d-苯丙胺的厌食作用具有抗性。这种对苯丙胺厌食的抗性似乎并非归因于糖尿病大鼠饥饿动机的增加，而是由于药物在注射四氧嘧啶的动物中作用减弱。这一结论得到了进一步实验的支持，这些实验表明，注射四氧嘧啶的大鼠在给予苯丙胺后运动活动和刻板行为减少。此外，苯丙胺抗性似乎是糖尿病状态的结果，因为通过给予精蛋白锌胰岛素十天，注射四氧嘧啶的大鼠中苯丙胺诱导的刻板行为可以恢复。这些研究结果表明，糖尿病大鼠对d-苯丙胺存在中枢神经系统反应改变。讨论了此类动物中含中枢儿茶酚胺神经元功能异常的可能性。
