Schreiber H, Bell R, Conely L, Kufner M, Palet J, Wright L
Pharmacol Biochem Behav. 1976 Dec;5(6):687-90. doi: 10.1016/0091-3057(76)90312-9.
This experiment determined whether reaction to a novel stimulus was diminished in a dose-dependent fashion following 8 consecutive days of d-amphetamine administration. Thirty-two male rats were injected with saline, 0.5, 2.5, or 5.0 mg/kg of d-amphetamine (each N = 8). On the ninth day, all animals received saline injections and were tested (a) in the presence of a novel stimulus, or (b) in the absence of a novel stimulus. Reaction to the novel stimulus varied inversely with the dose of d-amphetamine which had been received during the drug administration period. This reduction in reaction to the novel stimulus did not seem to depend on (a) the level of amphetamine-induced sterotypy at the end of the drug administration period (b) general reduction of activity, or (c) interference by drug-conditioned responses.
本实验旨在确定连续8天给予d-苯丙胺后，对新刺激的反应是否会以剂量依赖的方式减弱。32只雄性大鼠分别注射生理盐水、0.5、2.5或5.0mg/kg的d-苯丙胺（每组N = 8）。在第9天，所有动物均接受生理盐水注射，并在（a）新刺激存在的情况下，或（b）无新刺激的情况下进行测试。对新刺激的反应与给药期内所接受的d-苯丙胺剂量呈反比。对新刺激反应的这种降低似乎并不取决于（a）给药期末苯丙胺诱导的刻板行为水平，（b）活动的总体减少，或（c）药物条件反应的干扰。
