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[早期个体发育期间施加应激对幼鼠回避反应的影响]

[Effect of exposure to stress applied during early ontogenesis on the avoidance reaction in young rats].

作者信息

Sokolova E V

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1978 Mar-Apr;28(2):343-7.

PMID:565998
Abstract

A study was made of the influence of stress (swinging) applied on the first to the fifth day of life of newborn rats, on acquistion of active unilateral avoidance, passive avoidance of a dark "dangerous" compartment, the relative weight of the brain and absolute increase in the weight of the body at an early age. It was shown that in four-week old rats the stress significantly worsens active avoidance acquisition. In two-month old animals avoidance of a dark "dangerous" compartment, i.e. "passive" avoidance, tested immediately after application of electric current is more pronounced in stressed rats. No difference was found in the relative weight of the brain and the absolute increase in the weight of the body between control and stress groups of the animals.

摘要

研究了在新生大鼠出生后第1天至第5天施加应激(摆动)对其主动单侧回避学习、被动回避黑暗“危险”隔室、脑相对重量以及早期体重绝对增加的影响。结果表明,在4周龄大鼠中,应激显著恶化主动回避学习。在2月龄动物中,施加电流后立即测试发现,应激大鼠对黑暗“危险”隔室的回避,即“被动”回避更为明显。在动物的对照组和应激组之间,未发现脑相对重量和体重绝对增加有差异。

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